| Gene Information | |
|---|---|
| Gene Name | TRAIP |
| Organism | Homo sapiens (Human) |
| Gene Length | 469 |
| Protein Names | E3 ubiquitin-protein ligase TRAIP (EC 2.3.2.27) (RING finger protein 206) (TRAF-interacting protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000183763 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BWF2 |
| Gene Card | TRAIP |
| Uniprot ID | Q9BWF2 |
| Pfam | PF13639 |
| In ASD | no |
| Allosteric Prediction | no (-0.836893968) |
| Ortholog in Animals | Alpaca_ TRAIP ( ortholog_one2one ) Dog_ TRAIP ( ortholog_one2one ) GuineaPig_ TRAIP ( ortholog_one2one ) Macaque_ TRAIP ( ortholog_one2one ) Mouse_ Traip ( ortholog_one2one ) Pig_ TRAIP ( ortholog_one2one ) Rat_ Traip ( ortholog_one2one ) Rabbit_ TRAIP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | testis, zone.of.skin |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4ZTD (X-ray 2.20A ) |
| DBSNP | rs864622784 |
| Subcellular location [CC] | Nucleus, nucleoplasm {ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:26595769, ECO:0000269|PubMed:26820530, ECO:0000269|PubMed:30165463}. Nucleus, nucleolus {ECO:0000269|PubMed:14676304, ECO:0000269|PubMed:24553286, ECO:0000269|PubMed:25335891, ECO:0000269|PubMed:27462463, ECO:0000269|PubMed:30165463}. Chromosome {ECO:0000269|PubMed:25335891, ECO:0000269|PubMed:26595769, ECO:0000269|PubMed:26711499, ECO:0000269|PubMed:26781088, ECO:0000269|PubMed:30165463}. Cytoplasm. Cytoplasm, perinuclear region {ECO:0000269|PubMed:14676304}. Note=In the nucleus, found in close proximity to PCNA, suggesting localization at replication foci (PubMed:26595769). Localizes to DNA damage sites in response to replication stress (PubMed:26781088, PubMed:26595769, PubMed:26711499). {ECO:0000269|PubMed:26595769, ECO:0000269|PubMed:26711499, ECO:0000269|PubMed:26781088}. |
| Mouse PG classification | LPG |
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