| Gene Information | |
|---|---|
| Gene Name | TRAF4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 470 |
| Protein Names | TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000076604 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BUZ4 |
| Gene Card | TRAF4 |
| Uniprot ID | Q9BUZ4 |
| Pfam | PF00097; PF02176 |
| In ASD | no |
| Allosteric Prediction | no (-0.189800477) |
| Ortholog in Animals | Alpaca_ TRAF4 ( ortholog_one2one ) Dog_ TRAF4 ( ortholog_one2one ) GuineaPig_ TRAF4 ( ortholog_one2one ) Macaque_ TRAF4 ( ortholog_one2one ) Mouse_ Traf4 ( ortholog_one2one ) Pig_ TRAF4 ( ortholog_one2one ) Rat_ Traf4 ( ortholog_one2one ) Rabbit_ TRAF4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TRAF3, TRAF6, TRAF1, TRAF5, TRAF2 |
| Tissue | NA |
| Tissue Specificity | Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus. {ECO:0000269|PubMed:7592751, ECO:0000269|PubMed:9626059}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2EOD (NMR - ) 2YUC (NMR - ) 3ZJB (X-ray 1.84A ) 4K8U (X-ray 2.30A ) 4M4E (X-ray 2.60A ) 5YC1 (X-ray 2.51A ) |
| DBSNP | rs35932778 rs1044066 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:32268273}. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton {ECO:0000305}. |
| Mouse PG classification | NA |
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