| Gene Information | |
|---|---|
| Gene Name | TRAD |
| Organism | Homo sapiens (Human) |
| Gene Length | 2986 |
| Protein Names | Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | NA |
| Gene Card | KALRN |
| Uniprot ID | O60229 |
| Pfam | PF13716; PF00041; PF07679; PF00169; PF00069; PF00621; PF00435 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle. {ECO:0000269|PubMed:10023074}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.011765(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5QQD (X-ray 1.91A ) 5QQE (X-ray 1.95A ) 5QQF (X-ray 2.26A ) 5QQG (X-ray 2.23A ) 5QQH (X-ray 2.09A ) 5QQI (X-ray 2.08A ) 5QQJ (X-ray 1.90A ) 5QQK (X-ray 2.24A ) 5QQL (X-ray 2.25A ) 5QQM (X-ray 2.02A ) 5QQN (X-ray 2.26A ) 5QU9 (X-ray 2.00A ) |
| DBSNP | rs1187034389 rs2289838 rs35298864 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10023074}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10023074}. Note=Associated with the cytoskeleton. |
| Mouse PG classification | NA |
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