Gene Information
Gene NameTFRC
OrganismHomo sapiens (Human)
Gene Length760
Protein NamesTransferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]
Target Nametransferrin receptor
Target TypeNA
Gene Age544 ( ENSG00000072274 )
Evolutionary StageEuk+Bac
AlphaFoldDBP02786
Gene CardTFRC
Uniprot IDP02786
PfamPF02225; PF04389; PF04253
In ASDno
Allosteric Predictionyes (0.765094477)
Ortholog in AnimalsAlpaca_ TFRC ( ortholog_one2one )
Dog_ TFRC ( ortholog_one2one )
GuineaPig_ TFRC ( ortholog_one2one )
Macaque_ TFRC ( ortholog_one2one )
Mouse_ Tfrc ( ortholog_one2one )
Pig_ TFRC ( ortholog_one2one )
Rat_ Tfrc ( ortholog_one2one )
Rabbit_ TFRC ( ortholog_one2one )
OhnologsTFR2
ParalogsTFR2, NAALADL2, NAALAD2, FOLH1, NAALADL1
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001704(Rat);0.030769(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1CX8  (X-ray  3.20A  )  1DE4  (X-ray  2.80A  )  1SUV  (EM  7.50A  )  2NSU  (EM  27.00A  )  3KAS  (X-ray  2.40A  )  3S9L  (X-ray  3.22A  )  3S9M  (X-ray  3.32A  )  3S9N  (X-ray  3.25A  )  6D03  (EM  3.68A  )  6D04  (EM  3.74A  )  6D05  (EM  3.80A  )  6GSR  (EM  5.50A  )  6H5I  (EM  3.90A  )  6OKD  (X-ray  1.85A  )  6W3H  (X-ray  3.38A  )  6WRV  (X-ray  2.47A  )  6WRW  (X-ray  2.84A  )  6WRX  (X-ray  3.07A  )  6Y76  (X-ray  1.98A  )  7ZQS  (EM  2.54A  ) 
DBSNP rs863225436  rs3817672  rs41301381  rs41295879  rs41298067 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:17081065};
Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.;
[Transferrin receptor protein 1, serum form]: Secreted {ECO:0000269|PubMed:17081065}.
Mouse PG classificationNA
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