| Gene Information | |
|---|---|
| Gene Name | TPPP |
| Organism | Homo sapiens (Human) |
| Gene Length | 219 |
| Protein Names | Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000171368 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O94811 |
| Gene Card | TPPP |
| Uniprot ID | O94811 |
| Pfam | PF05517 |
| In ASD | no |
| Allosteric Prediction | no (-0.22789023) |
| Ortholog in Animals | Alpaca_ TPPP ( ortholog_one2one ) GuineaPig_ TPPP ( ortholog_one2one ) Macaque_ TPPP ( ortholog_one2one ) Mouse_ Tppp ( ortholog_one2one ) Pig_ TPPP ( ortholog_one2one ) Rat_ Tppp ( ortholog_one2one ) Rabbit_ TPPP ( ortholog_one2one ) |
| Ohnologs | TPPP3, TPPP2 |
| Paralogs | TPPP2, TPPP3 |
| Tissue | brain |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:10083737}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.041379(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Golgi outpost {ECO:0000250|UniProtKB:D3ZQL7}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:D3ZQL7}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17105200}. Nucleus {ECO:0000269|PubMed:18028908}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:22328514}. Note=Specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity). Mainly localizes to the cytoskeleton (PubMed:18028908). Also found in the nucleus; however, nuclear localization is unclear and requires additional evidences (PubMed:18028908). Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies (PubMed:15590652, PubMed:17027006). During mitosis, colocalizes with LIMK2 at the mitotic spindle (PubMed:22328514). {ECO:0000250|UniProtKB:D3ZQL7, ECO:0000269|PubMed:15590652, ECO:0000269|PubMed:17027006, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:22328514}. |
| Mouse PG classification | NA |
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