| Gene Information | |
|---|---|
| Gene Name | TPP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1249 |
| Protein Names | Tripeptidyl-peptidase 2 (TPP-2) (EC 3.4.14.10) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase II) (TPP-II) |
| Target Name | tripeptidyl-peptidase ii |
| Target Type | Discontinued target |
| Gene Age | 1488 ( ENSG00000134900 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P29144 |
| Gene Card | TPP2 |
| Uniprot ID | P29144 |
| Pfam | PF00082; PF12580 |
| In ASD | no |
| Allosteric Prediction | yes (0.111223195) |
| Ortholog in Animals | Alpaca_ TPP2 ( ortholog_one2one ) Dog_ TPP2 ( ortholog_one2one ) GuineaPig_ TPP2 ( ortholog_one2one ) Macaque_ TPP2 ( ortholog_one2one ) Mouse_ Tpp2 ( ortholog_one2one ) Pig_ TPP2 ( ortholog_one2one ) Rat_ Tpp2 ( ortholog_one2one ) Rabbit_ TPP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PCSK1, PCSK6, MBTPS1, PCSK7, PCSK5, PCSK9, PCSK4, FURIN, PCSK2 |
| Tissue | substantia.nigra, testis, zone.of.skin |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.002240(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1879008406 rs1882325267 rs760347832 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:19747897}. Nucleus {ECO:0000269|PubMed:19747897}. Note=Translocates to the nucleus in response to gamma-irradiation. |
| Mouse PG classification | NA |
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