Gene Information
Gene NameTPP1
OrganismHomo sapiens (Human)
Gene Length563
Protein NamesTripeptidyl-peptidase 1 (TPP-1) (EC 3.4.14.9) (Cell growth-inhibiting gene 1 protein) (Lysosomal pepstatin-insensitive protease) (LPIC) (Tripeptidyl aminopeptidase) (Tripeptidyl-peptidase I) (TPP-I)
Target Nametripeptidyl-peptidase i
Target TypeSuccessful target
Gene Age645 ( ENSG00000166340 )
Evolutionary StageEuk+Bac
AlphaFoldDBO14773
Gene CardTPP1
Uniprot IDO14773
PfamPF00082; PF09286
In ASDno
Allosteric Predictionyes (0.003642718)
Ortholog in AnimalsAlpaca_ TPP1 ( ortholog_one2one )
Dog_ TPP1 ( ortholog_one2one )
GuineaPig_ TPP1 ( ortholog_one2one )
Macaque_ TPP1 ( ortholog_one2one )
Mouse_ Tpp1 ( ortholog_one2one )
Pig_ TPP1 ( ortholog_one2one )
Rat_ Tpp1 ( ortholog_one2one )
Rabbit_ TPP1 ( ortholog_one2one )
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityDetected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3EDY  (X-ray  1.85A  )  3EE6  (X-ray  2.35A  ) 
DBSNP rs2734715  rs121908195  rs1800746  rs121908204  rs1554902028  rs764922748  rs34758634  rs121908205  rs28940573  rs121908209  rs1218678626  rs757953998  rs121908207  rs796053439  rs796053439  rs119455957  rs119455958  rs121908196  rs765380155  rs121908197  rs121908206  rs119455953  rs119455954  rs121908198  rs121908199  rs121908200  rs119455956  rs121908201  rs398122959  rs121908203  rs121908202  rs121908208  rs121908210  rs1348967263 
Subcellular location [CC]Lysosome {ECO:0000269|PubMed:19941651}. Melanosome {ECO:0000269|PubMed:12643545}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12643545}.
Mouse PG classificationHPG
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