| Gene Information | |
|---|---|
| Gene Name | TPO |
| Organism | Homo sapiens (Human) |
| Gene Length | 933 |
| Protein Names | Thyroid peroxidase (TPO) (EC 1.11.1.8) |
| Target Name | thyroid peroxidase |
| Target Type | Successful target |
| Gene Age | 987 ( ENSG00000115705 ) 3 ( ENSG00000277603 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P07202 |
| Gene Card | TPO |
| Uniprot ID | P07202 |
| Pfam | PF03098; PF07645; PF00084 |
| In ASD | no |
| Allosteric Prediction | yes (0.132498963) |
| Ortholog in Animals | Alpaca_ TPO ( ortholog_one2one ) Dog_ TPO ( ortholog_one2one ) Macaque_ TPO ( ortholog_one2one ) Mouse_ Tpo ( ortholog_one2one ) Pig_ TPO ( ortholog_one2one ) Rat_ Tpo ( ortholog_one2one ) Rabbit_ TPO ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PXDNL, EPX, PXDN, LPO, MPO |
| Tissue | thyroid |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1427024341 rs4927611 rs371367459 rs2280132 rs1297312788 rs2175977 rs1173922703 rs1035791118 rs104893669 rs121908083 rs1231870370 rs201165648 rs778515113 rs1169072188 rs779434941 rs121908084 rs10189135 rs121908086 rs121908088 rs776742629 rs121908087 rs13431173 rs732609 rs138931129 rs28991293 rs121908085 rs935058009 rs146351101 rs28913014 rs1126799 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface. |
| Mouse PG classification | HPG |
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