| Gene Information | |
|---|---|
| Gene Name | TPMT |
| Organism | Homo sapiens (Human) |
| Gene Length | 245 |
| Protein Names | Thiopurine S-methyltransferase (EC 2.1.1.67) (Thiopurine methyltransferase) |
| Target Name | thiopurine s-methyltransferase |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000137364 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P51580 |
| Gene Card | TPMT |
| Uniprot ID | P51580 |
| Pfam | PF05724 |
| In ASD | no |
| Allosteric Prediction | yes (0.356515565) |
| Ortholog in Animals | Alpaca_ TPMT ( ortholog_one2one ) Dog_ TPMT ( ortholog_one2one ) GuineaPig_ TPMT ( ortholog_one2one ) Macaque_ TPMT ( ortholog_one2one ) Mouse_ Tpmt ( ortholog_one2one ) Pig_ TPMT ( ortholog_one2one ) Rat_ Tpmt ( ortholog_one2one ) Rabbit_ TPMT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2BZG (X-ray 1.58A ) 2H11 (X-ray 1.89A ) |
| DBSNP | rs72552740 rs1800462 rs1800460 rs6921269 rs75543815 rs56161402 rs72552736 rs1142345 |
| Subcellular location [CC] | Cytoplasm. |
| Mouse PG classification | NA |
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