| Gene Information | |
|---|---|
| Gene Name | GNRHR |
| Organism | Homo sapiens (Human) |
| Gene Length | 328 |
| Protein Names | Gonadotropin-releasing hormone receptor (GnRH receptor) (GnRH-R) |
| Target Name | gonadotropin-releasing hormone receptor |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000109163 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P30968 |
| Gene Card | GNRHR |
| Uniprot ID | P30968 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.198602516) |
| Ortholog in Animals | Alpaca_ GNRHR ( ortholog_one2one ) Dog_ GNRHR ( ortholog_one2one ) GuineaPig_ GNRHR ( ortholog_one2one ) Macaque_ GNRHR ( ortholog_one2one ) Mouse_ Gnrhr ( ortholog_one2one ) Rat_ Gnrhr ( ortholog_one2one ) Rabbit_ GNRHR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | QRFPR, NPFFR1, HCRTR2, HCRTR1, NPFFR2, CCKBR, CCKAR, OXTR, AVPR2, AVPR1B, AVPR1A, GPR150, GALR3, GPR22, FFAR4, GALR1 |
| Tissue | pituitary.gland |
| Tissue Specificity | Pituitary, ovary, testis, breast and prostate but not in liver and spleen. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7BR3 (X-ray 2.79A ) |
| DBSNP | rs104893843 rs774317793 rs886907903 rs1391808526 rs104893844 rs104893836 rs104893838 rs104893842 rs144900788 rs104893840 rs74452732 rs104893839 rs104893837 rs148499544 rs28933074 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | HPG |
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