| Gene Information | |
|---|---|
| Gene Name | TPCN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 752 |
| Protein Names | Two pore channel protein 2 (Two pore calcium channel protein 2) |
| Target Name | two pore calcium channel protein 2 |
| Target Type | Literature-reported target |
| Gene Age | 987 ( ENSG00000162341 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8NHX9 |
| Gene Card | TPCN2 |
| Uniprot ID | Q8NHX9 |
| Pfam | PF00520 |
| In ASD | no |
| Allosteric Prediction | yes (0.368852198) |
| Ortholog in Animals | Alpaca_ TPCN2 ( ortholog_one2one ) Dog_ TPCN2 ( ortholog_one2one ) GuineaPig_ TPCN2 ( ortholog_one2one ) Macaque_ TPCN2 ( ortholog_one2one ) Mouse_ Tpcn2 ( ortholog_one2one ) Pig_ TPCN2 ( ortholog_one2one ) Rat_ Tpcn2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SCN11A, CACNA1C, CATSPER1, CACNA1E, CACNA1I, SCN9A, CACNA1B, SCN7A, SCN3A, SCN5A, SCN2A, SCN1A, CACNA1A, CACNA1F, CACNA1H, CATSPER2, CACNA1G, SCN8A, NALCN, CACNA1D, CATSPER4, SCN10A, CACNA1S, CATSPER3, TPCN1, SCN4A |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed at high level in liver and kidney. {ECO:0000269|PubMed:19387438}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6NQ0 (EM 3.70A ) 6NQ1 (EM 3.50A ) 6NQ2 (EM 3.40A ) |
| DBSNP | rs3750965 rs35264875 rs2376558 rs3829241 |
| Subcellular location [CC] | Late endosome membrane {ECO:0000269|PubMed:32167471}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:20880839, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:31825310, ECO:0000269|PubMed:32167471}; Multi-pass membrane protein {ECO:0000255}. Melanosome membrane {ECO:0000269|PubMed:27140606}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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