| Gene Information | |
|---|---|
| Gene Name | TPCN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 816 |
| Protein Names | Two pore channel protein 1 (Two pore calcium channel protein 1) (Voltage-dependent calcium channel protein TPC1) |
| Target Name | two pore calcium channel protein 1 |
| Target Type | Literature-reported target |
| Gene Age | 645 ( ENSG00000186815 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9ULQ1 |
| Gene Card | TPCN1 |
| Uniprot ID | Q9ULQ1 |
| Pfam | PF00520 |
| In ASD | yes |
| Allosteric Prediction | yes (0.686340055) |
| Ortholog in Animals | Alpaca_ TPCN1 ( ortholog_one2one ) Dog_ TPCN1 ( ortholog_one2one ) GuineaPig_ TPCN1 ( ortholog_one2one ) Macaque_ TPCN1 ( ortholog_one2one ) Mouse_ Tpcn1 ( ortholog_one2one ) Pig_ TPCN1 ( ortholog_one2one ) Rat_ Tpcn1 ( ortholog_one2one ) Rabbit_ TPCN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | SCN11A, CACNA1C, CATSPER1, CACNA1E, CACNA1I, SCN9A, CACNA1B, SCN7A, SCN3A, SCN5A, SCN2A, SCN1A, CACNA1A, CACNA1F, CACNA1H, CATSPER2, CACNA1G, SCN8A, NALCN, CACNA1D, CATSPER4, SCN10A, CACNA1S, CATSPER3, TPCN2, SCN4A |
| Tissue | NA |
| Tissue Specificity | Highest expression found in the heart and kidney, and lowest expression found in the spleen. {ECO:0000269|PubMed:10574461}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:19620632, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:25722412}; Multi-pass membrane protein {ECO:0000269|PubMed:19620632}. Endosome membrane {ECO:0000269|PubMed:19620632, ECO:0000269|PubMed:20880839, ECO:0000269|PubMed:23063126, ECO:0000269|PubMed:25722412}; Multi-pass membrane protein {ECO:0000269|PubMed:19620632}. Early endosome membrane {ECO:0000250|UniProtKB:Q9EQJ0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9EQJ0}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9EQJ0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9EQJ0}. |
| Mouse PG classification | NA |
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