Gene Information
Gene NameMGAT4A
OrganismHomo sapiens (Human)
Gene Length535
Protein NamesAlpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (EC 2.4.1.145) (N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa) (GlcNAc-T IVa) (GnT-IVa) (N-acetylglucosaminyltransferase IVa) (UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa) [Cleaved into: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form]
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000071073 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ9UM21
Gene CardMGAT4A
Uniprot IDQ9UM21
PfamNA
In ASDno
Allosteric Predictionno (-0.288054633)
Ortholog in AnimalsAlpaca_ MGAT4A ( ortholog_one2one )
Dog_ MGAT4A ( ortholog_one2one )
GuineaPig_ MGAT4A ( ortholog_one2one )
Macaque_ MGAT4A ( ortholog_one2one )
Mouse_ Mgat4a ( ortholog_one2one )
Pig_ MGAT4A ( ortholog_one2one )
Rat_ Mgat4a ( ortholog_one2many )
Rabbit_ MGAT4A ( ortholog_one2one )
OhnologsMGAT4B, MGAT4C
ParalogsMGAT4B, MGAT4C, MGAT4D
TissueNA
Tissue SpecificityExpressed in pancreas, spleen, thymus, prostate, small intestine, peripheral blood leukocytes and lymph node. Strongly overexpressed in choriocarcinoma cancer cell lines. Down-regulated in pancreatic cancer. {ECO:0000269|PubMed:10024668}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC][Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A]: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9D4R2};
Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9D4R2}.;
[Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form]: Secreted {ECO:0000250|UniProtKB:O77836}.
Mouse PG classificationNA
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