| Gene Information | |
|---|---|
| Gene Name | TP73 |
| Organism | Homo sapiens (Human) |
| Gene Length | 636 |
| Protein Names | Tumor protein p73 (p53-like transcription factor) (p53-related protein) |
| Target Name | tumor protein p73 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000078900 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | O15350 |
| Gene Card | TP73 |
| Uniprot ID | O15350 |
| Pfam | PF00870; PF07710; PF07647 |
| In ASD | no |
| Allosteric Prediction | yes (0.690050713) |
| Ortholog in Animals | Alpaca_ TP73 ( ortholog_one2one ) GuineaPig_ TP73 ( ortholog_one2one ) Macaque_ TP73 ( ortholog_one2one ) Mouse_ Trp73 ( ortholog_one2one ) Pig_ TP73 ( ortholog_one2one ) Rat_ Tp73 ( ortholog_one2one ) |
| Ohnologs | TP63, TP53 |
| Paralogs | TP63, TP53 |
| Tissue | NA |
| Tissue Specificity | Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue. Expressed in the respiratory epithelium (PubMed:34077761). {ECO:0000269|PubMed:11753569, ECO:0000269|PubMed:16461361, ECO:0000269|PubMed:34077761}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001596(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1COK (NMR - ) 1DXS (X-ray 2.54A ) 2KBY (NMR - ) 2MPS (NMR - ) 2NB1 (NMR - ) 2WQI (X-ray 1.70A ) 2WQJ (X-ray 2.00A ) 2WTT (X-ray 2.30A ) 2XWC (X-ray 1.82A ) 3VD0 (X-ray 2.95A ) 3VD1 (X-ray 2.95A ) 3VD2 (X-ray 4.00A ) 4A63 (X-ray 2.27A ) 4G82 (X-ray 3.10A ) 4G83 (X-ray 4.00A ) 4GUO (X-ray 3.19A ) 4GUQ (X-ray 3.70A ) 5HOB (X-ray 1.22A ) 5HOC (X-ray 1.36A ) 5KBD (X-ray 2.80A ) 6FGS (NMR - ) 6IJQ (NMR - ) 7EZJ (X-ray 2.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:24314664}. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage. |
| Mouse PG classification | NA |
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