| Gene Information | |
|---|---|
| Gene Name | TP63 |
| Organism | Homo sapiens (Human) |
| Gene Length | 680 |
| Protein Names | Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000073282 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9H3D4 |
| Gene Card | TP63 |
| Uniprot ID | Q9H3D4 |
| Pfam | PF00870; PF07710; PF07647 |
| In ASD | no |
| Allosteric Prediction | no (-0.12675483) |
| Ortholog in Animals | Alpaca_ TP63 ( ortholog_one2one ) Dog_ TP63 ( ortholog_one2one ) GuineaPig_ TP63 ( ortholog_one2one ) Macaque_ TP63 ( ortholog_one2one ) Mouse_ Trp63 ( ortholog_one2one ) Pig_ TP63 ( ortholog_one2one ) Rat_ Tp63 ( ortholog_one2one ) Rabbit_ TP63 ( ortholog_one2one ) |
| Ohnologs | TP53, TP73 |
| Paralogs | TP73, TP53 |
| Tissue | esophagus, skin, esophagus.mucosa, lower.leg.skin, suprapubic.skin, vagina |
| Tissue Specificity | Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. {ECO:0000269|PubMed:11248048, ECO:0000269|PubMed:9774969}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1RG6 (NMR - ) 2NB1 (NMR - ) 2RMN (NMR - ) 2Y9T (NMR - ) 2Y9U (X-ray 1.60A ) 3QYM (X-ray 3.20A ) 3QYN (X-ray 2.50A ) 3US0 (X-ray 2.50A ) 3US1 (X-ray 2.80A ) 3US2 (X-ray 4.20A ) 3ZY0 (X-ray 1.90A ) 3ZY1 (X-ray 2.15A ) 4A9Z (X-ray 2.29A ) 6FGN (NMR - ) 6RU6 (X-ray 2.05A ) 6RU7 (X-ray 2.08A ) 6RU8 (X-ray 1.92A ) 7Z71 (X-ray 1.85A ) 7Z72 (X-ray 1.80A ) 7Z73 (X-ray 2.27A ) 7Z7E (X-ray 1.80A ) |
| DBSNP | rs193287780 rs1560274243 rs121908838 rs121908836 rs121908835 rs121908849 rs1205536026 rs121908840 rs121908839 rs886039442 rs113993967 rs121908841 rs886041251 rs121908837 rs121908844 rs121908847 rs121908845 rs121908842 rs121908843 rs121908846 rs767906723 rs113993963 rs113993963 rs113993963 rs113993963 rs113993963 rs113993963 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12446779, ECO:0000269|PubMed:20123734}. |
| Mouse PG classification | HPG |
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