| Gene Information | |
|---|---|
| Gene Name | TP53RK |
| Organism | Homo sapiens (Human) |
| Gene Length | 253 |
| Protein Names | EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000172315 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q96S44 |
| Gene Card | TP53RK |
| Uniprot ID | Q96S44 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.277186716) |
| Ortholog in Animals | Alpaca_ TP53RK ( ortholog_one2one ) Dog_ TP53RK ( ortholog_one2one ) GuineaPig_ TP53RK ( ortholog_one2one ) Macaque_ TP53RK ( ortholog_one2one ) Mouse_ Trp53rka ( ortholog_one2many ) Mouse_ Trp53rkb ( ortholog_one2many ) Pig_ TP53RK ( ortholog_one2one ) Rat_ Tp53rk ( ortholog_one2many ) Rabbit_ TP53RK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in testis. Weakly expressed in heart kidney and spleen. {ECO:0000269|PubMed:11546806}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001899(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6WQX (X-ray 2.53A ) |
| DBSNP | rs773814837 rs1432218739 rs34983477 rs11550540 rs56008408 rs776588426 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:28805828}. Nucleus {ECO:0000269|PubMed:22912744, ECO:0000269|PubMed:27903914, ECO:0000269|PubMed:28805828}. |
| Mouse PG classification | NA |
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