| Gene Information | |
|---|---|
| Gene Name | TP53BP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1128 |
| Protein Names | Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000143514 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13625 |
| Gene Card | TP53BP2 |
| Uniprot ID | Q13625 |
| Pfam | PF12796; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (0.078316685) |
| Ortholog in Animals | Alpaca_ TP53BP2 ( ortholog_one2one ) Dog_ TP53BP2 ( ortholog_one2one ) GuineaPig_ TP53BP2 ( ortholog_one2one ) Macaque_ TP53BP2 ( ortholog_one2one ) Mouse_ Trp53bp2 ( ortholog_one2one ) Pig_ TP53BP2 ( ortholog_one2one ) Rat_ Tp53bp2 ( ortholog_one2one ) Rabbit_ TP53BP2 ( ortholog_one2one ) |
| Ohnologs | PPP1R13B |
| Paralogs | PPP1R13B |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines. {ECO:0000269|PubMed:10498867, ECO:0000269|PubMed:10631318, ECO:0000269|PubMed:11684014}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1YCS (X-ray 2.20A ) 2UWQ (NMR - ) 4A63 (X-ray 2.27A ) 4IRV (X-ray 2.04A ) 6GHM (X-ray 2.15A ) 6HKP (X-ray 1.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, perinuclear region. Nucleus. Note=Predominantly found in the perinuclear region. Some small fraction is nuclear. Sequester in the cytoplasm on overexpression of DDX42. |
| Mouse PG classification | NA |
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