| Gene Information | |
|---|---|
| Gene Name | TOX |
| Organism | Homo sapiens (Human) |
| Gene Length | 526 |
| Protein Names | Thymocyte selection-associated high mobility group box protein TOX (Thymus high mobility group box protein TOX) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000198846 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O94900 |
| Gene Card | TOX |
| Uniprot ID | O94900 |
| Pfam | PF00505 |
| In ASD | no |
| Allosteric Prediction | no (-1.366168146) |
| Ortholog in Animals | Alpaca_ TOX ( ortholog_one2one ) Dog_ TOX ( ortholog_one2one ) GuineaPig_ TOX ( ortholog_one2one ) Macaque_ TOX ( ortholog_one2one ) Mouse_ Tox ( ortholog_one2one ) Pig_ TOX ( ortholog_one2one ) Rat_ Tox ( ortholog_one2one ) Rabbit_ TOX ( ortholog_one2one ) |
| Ohnologs | TOX4, TOX3, TOX2 |
| Paralogs | SP140, HMGB2, UBTF, TOX4, UBTFL1, HMGB1P1, HMGB1, SP100, SMARCE1, HMGB3, HMG20A, TFAM, HMG20B, SSRP1, TOX2, SP110, HMGB4, SP140L, HMGXB4, TOX3 |
| Tissue | NA |
| Tissue Specificity | Expressed in NK cells (PubMed:21126536). Highly expressed in tumor-infiltrating CD8-positive T cells (at protein level) (PubMed:31207604). {ECO:0000269|PubMed:21126536, ECO:0000269|PubMed:31207604}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. |
| Mouse PG classification | NA |
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