Gene Information
Gene NameTOSS
OrganismHomo sapiens (Human)
Gene Length313
Protein NamesPotassium channel subfamily K member 6 (Inward rectifying potassium channel protein TWIK-2) (TWIK-originated similarity sequence)
Target NameNA
Target TypeNA
Gene AgeNA
Evolutionary StageNA
AlphaFoldDBQ9Y257
Gene CardKCNK6
Uniprot IDQ9Y257
PfamPF07885
In ASDno
Allosteric PredictionNA
Ortholog in AnimalsNA
OhnologsNA
ParalogsNA
TissueNA
Tissue SpecificityWidespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus. Lowest expression detected in brain.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs35762773  rs35496032  rs34989303 
Subcellular location [CC]Membrane {ECO:0000305};
Multi-pass membrane protein {ECO:0000305}.
Mouse PG classificationNA
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