| Gene Information | |
|---|---|
| Gene Name | NAE1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 534 |
| Protein Names | NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1) |
| Target Name | nedd8-activating enzyme e1 regulatory subunit |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000159593 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13564 |
| Gene Card | NAE1 |
| Uniprot ID | Q13564 |
| Pfam | PF00899 |
| In ASD | no |
| Allosteric Prediction | yes (0.165377477) |
| Ortholog in Animals | Alpaca_ NAE1 ( ortholog_one2one ) Dog_ NAE1 ( ortholog_one2one ) GuineaPig_ NAE1 ( ortholog_one2one ) Macaque_ NAE1 ( ortholog_one2one ) Mouse_ Nae1 ( ortholog_one2one ) Rat_ Nae1 ( ortholog_one2one ) Rabbit_ NAE1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UBA7, UBA3, UBA6, UBA2, UBA1, UBA5, MOCS3, ATG7, SAE1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous in fetal tissues. Expressed throughout the adult brain. {ECO:0000269|PubMed:8626687}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001578(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1R4M (X-ray 3.00A ) 1R4N (X-ray 3.60A ) 1TT5 (X-ray 2.60A ) 1YOV (X-ray 2.60A ) 2NVU (X-ray 2.80A ) 3DBH (X-ray 2.85A ) 3DBL (X-ray 2.90A ) 3DBR (X-ray 3.05A ) 3GZN (X-ray 3.00A ) |
| DBSNP | rs363212 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:14557245}. Note=Colocalizes with APP in lipid rafts. |
| Mouse PG classification | NA |
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