| Gene Information | |
|---|---|
| Gene Name | WASF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 498 |
| Protein Names | Actin-binding protein WASF2 (Protein WAVE-2) (Verprolin homology domain-containing protein 2) (Wiskott-Aldrich syndrome protein family member 2) (WASP family protein member 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000158195 ) |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9Y6W5 |
| Gene Card | WASF2 |
| Uniprot ID | Q9Y6W5 |
| Pfam | PF02205 |
| In ASD | no |
| Allosteric Prediction | no (-0.294411403) |
| Ortholog in Animals | Alpaca_ WASF2 ( ortholog_one2one ) Dog_ WASF2 ( ortholog_one2one ) GuineaPig_ WASF2 ( ortholog_one2one ) Macaque_ WASF2 ( ortholog_one2one ) Mouse_ Wasf2 ( ortholog_one2one ) Pig_ WASF2 ( ortholog_one2one ) Rat_ Wasf2 ( ortholog_one2one ) Rabbit_ WASF2 ( ortholog_one2one ) |
| Ohnologs | WASF1, WASF3 |
| Paralogs | WASF1, WASF3 |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. {ECO:0000269|PubMed:10381382}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.289437(Rat);0.026087(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2A40 (X-ray 1.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Basolateral cell membrane {ECO:0000269|PubMed:30250061}. Note=At the interface between the lamellipodial actin meshwork and the membrane. {ECO:0000250}. |
| Mouse PG classification | NA |
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