| Gene Information | |
|---|---|
| Gene Name | TOP2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 1626 |
| Protein Names | DNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme) |
| Target Name | dna topoisomerase 2 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000077097 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q02880 |
| Gene Card | TOP2B |
| Uniprot ID | Q02880 |
| Pfam | PF00204; PF00521; PF08070; PF02518; PF01751; PF16898 |
| In ASD | no |
| Allosteric Prediction | no (-0.062284341) |
| Ortholog in Animals | Alpaca_ TOP2B ( ortholog_one2one ) Dog_ TOP2B ( ortholog_one2one ) GuineaPig_ TOP2B ( ortholog_one2one ) Macaque_ TOP2B ( ortholog_one2one ) Mouse_ Top2b ( ortholog_one2one ) Pig_ TOP2B ( ortholog_one2one ) Rat_ Top2b ( ortholog_one2one ) Rabbit_ TOP2B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TOP2A |
| Tissue | NA |
| Tissue Specificity | Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in breast, colon and lung carcinomas, Hodgkin's disease, large-cell non-Hodgkin's lymphoma, lymphocytic lymphomas and seminomas (PubMed:9155056). {ECO:0000269|PubMed:9155056}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.011765(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3QX3 (X-ray 2.16A ) 4G0U (X-ray 2.70A ) 4G0V (X-ray 2.55A ) 4G0W (X-ray 2.70A ) 4J3N (X-ray 2.30A ) 5GWI (X-ray 2.74A ) 5GWJ (X-ray 2.57A ) 5ZAD (X-ray 2.54A ) 5ZEN (X-ray 2.75A ) 5ZQF (X-ray 3.87A ) 5ZRF (X-ray 2.30A ) 7QFN (X-ray 2.62A ) 7QFO (X-ray 1.90A ) 7ZBG (X-ray 2.30A ) |
| DBSNP | rs886039770 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:8299728, ECO:0000269|PubMed:9155056}. Nucleus, nucleoplasm {ECO:0000269|PubMed:9155056}. Nucleus {ECO:0000269|PubMed:19690332}. |
| Mouse PG classification | NA |
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