Gene Information
Gene NameTOP2B
OrganismHomo sapiens (Human)
Gene Length1626
Protein NamesDNA topoisomerase 2-beta (EC 5.6.2.2) (DNA topoisomerase II, beta isozyme)
Target Namedna topoisomerase ii beta
Target TypeSuccessful target
Gene Age645 ( ENSG00000077097 )
Evolutionary StageEukaryota
AlphaFoldDBQ02880
Gene CardTOP2B
Uniprot IDQ02880
PfamPF00204; PF00521; PF08070; PF02518; PF01751; PF16898
In ASDno
Allosteric Predictionno (-0.062284341)
Ortholog in AnimalsAlpaca_ TOP2B ( ortholog_one2one )
Dog_ TOP2B ( ortholog_one2one )
GuineaPig_ TOP2B ( ortholog_one2one )
Macaque_ TOP2B ( ortholog_one2one )
Mouse_ Top2b ( ortholog_one2one )
Pig_ TOP2B ( ortholog_one2one )
Rat_ Top2b ( ortholog_one2one )
Rabbit_ TOP2B ( ortholog_one2one )
OhnologsNA
ParalogsTOP2A
TissueNA
Tissue SpecificityExpressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in breast, colon and lung carcinomas, Hodgkin's disease, large-cell non-Hodgkin's lymphoma, lymphocytic lymphomas and seminomas (PubMed:9155056). {ECO:0000269|PubMed:9155056}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.011765(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3QX3  (X-ray  2.16A  )  4G0U  (X-ray  2.70A  )  4G0V  (X-ray  2.55A  )  4G0W  (X-ray  2.70A  )  4J3N  (X-ray  2.30A  )  5GWI  (X-ray  2.74A  )  5GWJ  (X-ray  2.57A  )  5ZAD  (X-ray  2.54A  )  5ZEN  (X-ray  2.75A  )  5ZQF  (X-ray  3.87A  )  5ZRF  (X-ray  2.30A  )  7QFN  (X-ray  2.62A  )  7QFO  (X-ray  1.90A  )  7ZBG  (X-ray  2.30A  ) 
DBSNP rs886039770 
Subcellular location [CC]Nucleus, nucleolus {ECO:0000269|PubMed:8299728, ECO:0000269|PubMed:9155056}. Nucleus, nucleoplasm {ECO:0000269|PubMed:9155056}. Nucleus {ECO:0000269|PubMed:19690332}.
Mouse PG classificationNA
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