| Gene Information | |
|---|---|
| Gene Name | TOM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 492 |
| Protein Names | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000100284 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60784 |
| Gene Card | TOM1 |
| Uniprot ID | O60784 |
| Pfam | PF03127; PF00790 |
| In ASD | no |
| Allosteric Prediction | no (-0.192173726) |
| Ortholog in Animals | Alpaca_ TOM1 ( ortholog_one2one ) Dog_ TOM1 ( ortholog_one2one ) GuineaPig_ TOM1 ( ortholog_one2one ) Macaque_ TOM1 ( ortholog_one2one ) Mouse_ Tom1 ( ortholog_one2one ) Pig_ TOM1 ( ortholog_one2one ) Rat_ Tom1 ( ortholog_one2one ) Rabbit_ TOM1 ( ortholog_one2one ) |
| Ohnologs | TOM1L2 |
| Paralogs | WDFY2, STAM2, HGS, GGA1, WDFY1, TOM1L2, GGA3, STAM, GGA2, TOM1L1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highly expressed in skeletal muscle, heart, placenta and liver. {ECO:0000269|PubMed:10329004}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.022525(Mouse);0.001823(Rat);0.050000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1ELK (X-ray 1.50A ) 1WRD (X-ray 1.75A ) 2N2N (NMR - ) 2N9D (NMR - ) 6J56 (X-ray 1.80A ) |
| DBSNP | rs11558473 rs34371697 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:14563850, ECO:0000269|PubMed:14613930, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31263572}. Endosome membrane {ECO:0000269|PubMed:14613930, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:23023224, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31263572}; Peripheral membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582}; Peripheral membrane protein {ECO:0000305}. Note=Localized to endo/exosomal vesicles (PubMed:31263572). Enriched on signaling endosomes (PubMed:25588840). Recruited to early endosomes by TOLLIP and by PtdIns(5)P (PubMed:15047686, PubMed:25588840, PubMed:26320582). {ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:25588840, ECO:0000269|PubMed:26320582, ECO:0000269|PubMed:31263572}. |
| Mouse PG classification | NA |
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