| Gene Information | |
|---|---|
| Gene Name | TNS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1445 |
| Protein Names | Tensin-3 (Tensin-like SH2 domain-containing protein 1) (Tumor endothelial marker 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000136205 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q68CZ2 |
| Gene Card | TNS3 |
| Uniprot ID | Q68CZ2 |
| Pfam | PF08416; PF10409; PF00017 |
| In ASD | no |
| Allosteric Prediction | no (-1.000511017) |
| Ortholog in Animals | Alpaca_ TNS3 ( ortholog_one2one ) Dog_ TNS3 ( ortholog_one2one ) GuineaPig_ TNS3 ( ortholog_one2one ) Macaque_ TNS3 ( ortholog_one2one ) Mouse_ Tns3 ( ortholog_one2one ) Pig_ TNS3 ( ortholog_one2one ) Rat_ Tns3 ( ortholog_one2one ) |
| Ohnologs | TNS4, TNS1 |
| Paralogs | TNS1, HVCN1, PTEN, TPTE, TPTE2, TMEM266 |
| Tissue | NA |
| Tissue Specificity | Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas. {ECO:0000269|PubMed:11559528, ECO:0000269|PubMed:15140944, ECO:0000269|PubMed:16461921}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2293362 rs7808646 rs3807590 |
| Subcellular location [CC] | Cell junction, focal adhesion {ECO:0000269|PubMed:15140944, ECO:0000269|PubMed:17643115}. |
| Mouse PG classification | NA |
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