| Gene Information | |
|---|---|
| Gene Name | TNS |
| Organism | Homo sapiens (Human) |
| Gene Length | 1839 |
| Protein Names | Tensin-1 (EC 3.1.3.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9HBL0 |
| Gene Card | TNS1 |
| Uniprot ID | Q9HBL0 |
| Pfam | PF08416; PF10409; PF00017 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In the lung, detected in the alveolar septa (at protein level) (PubMed:28005397). Ubiquitous (PubMed:11023826). {ECO:0000269|PubMed:11023826, ECO:0000269|PubMed:28005397}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11680854 rs3815849 rs3796033 rs2571445 rs918949 rs3796028 |
| Subcellular location [CC] | Cell surface {ECO:0000269|PubMed:21768292}. Cell junction, focal adhesion {ECO:0000269|PubMed:19826001, ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:21768292}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21768292}. Note=Localizes to both focal adhesions and fibrillar adhesions (PubMed:20069572). Localized at the cell periphery preferentially to fibrillar adhesions rather than to focal adhesions. Translocates from the cell edge to the cell center in an ITGB1BP1-dependent manner (PubMed:21768292). {ECO:0000269|PubMed:20069572, ECO:0000269|PubMed:21768292}. |
| Mouse PG classification | NA |
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