| Gene Information | |
|---|---|
| Gene Name | TNPO3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 923 |
| Protein Names | Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000064419 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y5L0 |
| Gene Card | TNPO3 |
| Uniprot ID | Q9Y5L0 |
| Pfam | PF08389 |
| In ASD | no |
| Allosteric Prediction | no (-0.342934753) |
| Ortholog in Animals | Alpaca_ TNPO3 ( ortholog_one2one ) Dog_ TNPO3 ( ortholog_one2one ) GuineaPig_ TNPO3 ( ortholog_one2one ) Macaque_ TNPO3 ( ortholog_one2one ) Mouse_ Tnpo3 ( ortholog_one2one ) Pig_ TNPO3 ( ortholog_one2one ) Rat_ Tnpo3 ( ortholog_one2one ) Rabbit_ TNPO3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IPO13 |
| Tissue | NA |
| Tissue Specificity | Expressed in skeletal muscle. {ECO:0000269|PubMed:23667635}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.053333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4C0O (X-ray 2.56A ) 4C0P (X-ray 2.95A ) 4C0Q (X-ray 3.42A ) 4OL0 (X-ray 2.90A ) 6GX9 (X-ray 2.70A ) |
| DBSNP | rs587777431 rs587777431 |
| Subcellular location [CC] | Nucleus envelope {ECO:0000269|PubMed:31192305, ECO:0000305|PubMed:10713112, ECO:0000305|PubMed:23543484}. Cytoplasm {ECO:0000269|PubMed:10713112}. Note=Localizes to the nuclear envelope and annulate lamellae, which consists in stacks of endoplasmic reticulum membranes containing a high density of nuclear pores. {ECO:0000269|PubMed:31192305}. |
| Mouse PG classification | NA |
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