| Gene Information | |
|---|---|
| Gene Name | TNNT2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 298 |
| Protein Names | Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000118194 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P45379 |
| Gene Card | TNNT2 |
| Uniprot ID | P45379 |
| Pfam | PF00992 |
| In ASD | no |
| Allosteric Prediction | no (-0.037183239) |
| Ortholog in Animals | Alpaca_ TNNT2 ( ortholog_one2one ) Dog_ TNNT2 ( ortholog_one2one ) GuineaPig_ TNNT2 ( ortholog_one2one ) Macaque_ TNNT2 ( ortholog_one2one ) Mouse_ Tnnt2 ( ortholog_one2one ) Pig_ TNNT2 ( ortholog_one2one ) Rat_ Tnnt2 ( ortholog_one2one ) |
| Ohnologs | TNNT3 |
| Paralogs | TNNT1, TNNT3 |
| Tissue | heart, left.atrium, left.ventricle, mitral.valve, pulmonary.valve, tricuspid.valve, atrium |
| Tissue Specificity | Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.107143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1J1D (X-ray 2.61A ) 1J1E (X-ray 3.30A ) 4Y99 (X-ray 2.00A ) 6KN7 (EM 6.60A ) 6KN8 (EM 4.80A ) |
| DBSNP | rs200754249 rs886039053 rs121964855 rs121964856 rs121964856 rs397516456 rs397516457 rs727504245 rs121964858 rs121964858 rs2996496 rs397516463 rs2996496 rs74315380 rs74315379 rs727504246 rs121964860 rs45520032 rs45520032 rs2996495 rs45466197 rs3730238 rs4523540 rs863225119 rs121964857 rs397516484 rs367785431 |
| Subcellular location [CC] | NA |
| Mouse PG classification | HPG |
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