| Gene Information | |
|---|---|
| Gene Name | TNNI3K |
| Organism | Homo sapiens (Human) |
| Gene Length | 835 |
| Protein Names | Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase) |
| Target Name | serine/threonine-protein kinase tnni3k |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000116783 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q59H18 |
| Gene Card | TNNI3K |
| Uniprot ID | Q59H18 |
| Pfam | PF12796; PF13637; PF07714 |
| In ASD | no |
| Allosteric Prediction | no (-0.20022057) |
| Ortholog in Animals | Alpaca_ TNNI3K ( ortholog_one2one ) Dog_ TNNI3K ( ortholog_one2one ) Macaque_ TNNI3K ( ortholog_one2one ) Mouse_ Tnni3k ( ortholog_one2one ) Pig_ TNNI3K ( ortholog_one2one ) Rat_ Tnni3k ( ortholog_one2one ) Rabbit_ TNNI3K ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LIMK2, RIPK1, LRRK2, TESK2, KSR2, MAP3K10, RIPK2, MOS, MAP3K9, MLKL, MAP3K20, ARAF, TESK1, MAP3K13, BRAF, ILK, MAP3K11, RAF1, MAP3K12, MAP3K21, LIMK1, KSR1, RIPK3 |
| Tissue | heart, left.ventricle, mitral.valve, pulmonary.valve |
| Tissue Specificity | Highly expressed in both adult and fetal heart. {ECO:0000269|PubMed:12721663}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4YFF (X-ray 3.07A ) 4YFI (X-ray 2.70A ) 6B5J (X-ray 2.97A ) 7MGJ (X-ray 2.95A ) 7MGK (X-ray 3.10A ) |
| DBSNP | rs34874695 rs34521608 rs34335537 rs606231469 rs2274260 rs3737564 rs45578635 rs201613442 rs45614933 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12721663}. Cytoplasm {ECO:0000269|PubMed:12721663}. Note=Expressed at lower levels in the cytoplasm. |
| Mouse PG classification | NA |
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