| Gene Information | |
|---|---|
| Gene Name | TNN |
| Organism | Homo sapiens (Human) |
| Gene Length | 1299 |
| Protein Names | Tenascin-N (TN-N) (Tenascin-W) (TN-W) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000120332 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UQP3 |
| Gene Card | TNN |
| Uniprot ID | Q9UQP3 |
| Pfam | PF18720; PF00147; PF00041 |
| In ASD | no |
| Allosteric Prediction | no (-0.81713312) |
| Ortholog in Animals | Alpaca_ TNN ( ortholog_one2one ) Dog_ TNN ( ortholog_one2one ) GuineaPig_ TNN ( ortholog_one2one ) Macaque_ TNN ( ortholog_one2one ) Mouse_ Tnn ( ortholog_one2one ) Pig_ TNN ( ortholog_one2one ) Rat_ Tnn ( ortholog_one2one ) Rabbit_ TNN ( ortholog_one2one ) |
| Ohnologs | TNC |
| Paralogs | TNC, FCN1, ANGPTL5, FGL1, FCN2, ANGPTL4, FIBCD1, ANGPTL6, TNXB, FGB, ANGPT4, ANGPTL1, MFAP4, TNR, ANGPTL3, FGA, ANGPTL2, ANGPTL7, FCN3, FNDC7, FGL2, FGG, ANGPT1, FN1, ANGPT2 |
| Tissue | adipose.tissue, pineal.gland |
| Tissue Specificity | Not detected in normal adult mammary tissues or brain but expressed in most breast tumors and brain tumors, such as glioblastomas, astrocytomas and oligodendrogliomas, tested (PubMed:17909022, PubMed:19884327). In brain tumors, detected around the endothelial cell layer of the clood vessels (PubMed:19884327). {ECO:0000269|PubMed:17909022, ECO:0000269|PubMed:19884327}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002657(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs2072032 rs16847812 rs6664276 rs17374761 rs6696455 rs6694078 rs2285215 rs10798333 rs10158841 rs2072036 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:19884327}. |
| Mouse PG classification | NA |
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