Gene Information | |
---|---|
Gene Name | TNKS2 |
Organism | Homo sapiens (Human) |
Gene Length | 1166 |
Protein Names | Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein) |
Target Name | tankyrase-2 |
Target Type | Clinical trial target |
Gene Age | 680 ( ENSG00000107854 ) |
Evolutionary Stage | Eukaryota |
AlphaFoldDB | Q9H2K2 |
Gene Card | TNKS2 |
Uniprot ID | Q9H2K2 |
Pfam | PF00023; PF12796; PF13637; PF13857; PF00644; PF07647 |
In ASD | no |
Allosteric Prediction | no (-0.523602322) |
Ortholog in Animals | Alpaca_ TNKS2 ( ortholog_one2one ) Dog_ TNKS2 ( ortholog_one2one ) GuineaPig_ TNKS2 ( ortholog_one2one ) Macaque_ TNKS2 ( ortholog_one2one ) Mouse_ Tnks2 ( ortholog_one2one ) Pig_ TNKS2 ( ortholog_one2one ) Rat_ Tnks2 ( ortholog_one2one ) Rabbit_ TNKS2 ( ortholog_one2one ) |
Ohnologs | TNKS |
Paralogs | ANKRD45, TNKS |
Tissue | NA |
Tissue Specificity | Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain. |
Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.022222(Rabbit) |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 2Y0I (X-ray 2.28A ) 3KR7 (X-ray 1.95A ) 3KR8 (X-ray 2.10A ) 3MHJ (X-ray 1.80A ) 3MHK (X-ray 2.30A ) 3P0N (X-ray 1.90A ) 3P0P (X-ray 2.49A ) 3P0Q (X-ray 1.90A ) 3TWQ (X-ray 2.15A ) 3TWR (X-ray 1.55A ) 3TWS (X-ray 1.70A ) 3TWT (X-ray 1.85A ) 3TWU (X-ray 1.80A ) 3TWV (X-ray 2.30A ) 3TWW (X-ray 2.00A ) 3TWX (X-ray 1.80A ) 3U9H (X-ray 1.75A ) 3U9Y (X-ray 2.30A ) 3UA9 (X-ray 2.15A ) 3W51 (X-ray 2.00A ) 4AVU (X-ray 2.40A ) 4AVW (X-ray 2.15A ) 4BFP (X-ray 2.40A ) 4BJ9 (X-ray 2.05A ) 4BJB (X-ray 2.30A ) 4BJC (X-ray 2.20A ) 4BS4 (X-ray 1.89A ) 4BU3 (X-ray 2.15A ) 4BU5 (X-ray 1.80A ) 4BU6 (X-ray 1.80A ) 4BU7 (X-ray 2.05A ) 4BU8 (X-ray 1.85A ) 4BU9 (X-ray 1.65A ) 4BUA (X-ray 1.85A ) 4BUD (X-ray 2.50A ) 4BUE (X-ray 1.60A ) 4BUF (X-ray 2.50A ) 4BUI (X-ray 1.95A ) 4BUS (X-ray 1.90A ) 4BUT (X-ray 1.90A ) 4BUU (X-ray 1.60A ) 4BUV (X-ray 1.80A ) 4BUW (X-ray 1.85A ) 4BUX (X-ray 1.95A ) 4BUY (X-ray 1.90A ) 4HKI (X-ray 2.15A ) 4HKK (X-ray 1.95A ) 4HKN (X-ray 2.05A ) 4HL5 (X-ray 2.20A ) 4HLF (X-ray 2.15A ) 4HLG (X-ray 2.00A ) 4HLH (X-ray 1.75A ) 4HLK (X-ray 2.00A ) 4HLM (X-ray 1.95A ) 4HMH (X-ray 2.30A ) 4HYF (X-ray 2.80A ) 4IUE (X-ray 2.38A ) 4J1Z (X-ray 2.00A ) 4J21 (X-ray 1.93A ) 4J22 (X-ray 2.12A ) 4J3L (X-ray 2.09A ) 4J3M (X-ray 1.90A ) 4KZL (X-ray 2.00A ) 4KZQ (X-ray 2.25A ) 4KZU (X-ray 2.10A ) 4L09 (X-ray 2.05A ) 4L0B (X-ray 1.80A ) 4L0I (X-ray 2.30A ) 4L0S (X-ray 1.90A ) 4L0T (X-ray 2.10A ) 4L0V (X-ray 1.70A ) 4L10 (X-ray 1.70A ) 4L2F (X-ray 2.05A ) 4L2G (X-ray 2.05A ) 4L2K (X-ray 2.10A ) 4L31 (X-ray 2.00A ) 4L32 (X-ray 1.85A ) 4L33 (X-ray 2.10A ) 4L34 (X-ray 1.80A ) 4M7B (X-ray 1.95A ) 4PML (X-ray 1.87A ) 4PNL (X-ray 1.50A ) 4PNM (X-ray 2.19A ) 4PNN (X-ray 1.65A ) 4PNQ (X-ray 1.85A ) 4PNR (X-ray 1.71A ) 4PNS (X-ray 1.65A ) 4PNT (X-ray 1.60A ) 4TJU (X-ray 1.57A ) 4TJW (X-ray 1.70A ) 4TJY (X-ray 1.90A ) 4TK0 (X-ray 1.65A ) 4TK5 (X-ray 2.02A ) 4TKF (X-ray 2.60A ) 4TKG (X-ray 1.95A ) 4TKI (X-ray 2.15A ) 4UFU (X-ray 2.10A ) 4UFY (X-ray 1.70A ) 4UHG (X-ray 1.70A ) 4UI3 (X-ray 2.00A ) 4UI4 (X-ray 2.40A ) 4UI5 (X-ray 1.65A ) 4UI6 (X-ray 1.80A ) 4UI7 (X-ray 1.80A ) 4UI8 (X-ray 2.05A ) 4UVL (X-ray 2.00A ) 4UVN (X-ray 2.20A ) 4UVO (X-ray 1.85A ) 4UVP (X-ray 1.75A ) 4UVS (X-ray 2.00A ) 4UVT (X-ray 1.95A ) 4UVU (X-ray 1.95A ) 4UVV (X-ray 1.90A ) 4UVW (X-ray 2.10A ) 4UVX (X-ray 1.95A ) 4UVY (X-ray 1.95A ) 4UVZ (X-ray 1.60A ) 4UX4 (X-ray 1.80A ) 4W5I (X-ray 1.95A ) 4Z68 (X-ray 1.86A ) 5ADQ (X-ray 2.10A ) 5ADR (X-ray 2.10A ) 5ADS (X-ray 1.80A ) 5ADT (X-ray 2.15A ) 5AEH (X-ray 1.85A ) 5AKU (X-ray 1.80A ) 5AKW (X-ray 2.07A ) 5AL1 (X-ray 1.75A ) 5AL2 (X-ray 1.90A ) 5AL3 (X-ray 1.75A ) 5AL4 (X-ray 1.90A ) 5AL5 (X-ray 2.05A ) 5BXO (X-ray 1.33A ) 5BXU (X-ray 1.35A ) 5C5P (X-ray 1.75A ) 5C5Q (X-ray 2.00A ) 5C5R (X-ray 1.55A ) 5DCZ (X-ray 2.23A ) 5FPF (X-ray 2.60A ) 5FPG (X-ray 2.75A ) 5JRT (X-ray 1.53A ) 5NOB (X-ray 1.85A ) 5NSP (X-ray 2.30A ) 5NUT (X-ray 1.60A ) 5OWS (X-ray 1.80A ) 5OWT (X-ray 2.20A ) 6TG4 (X-ray 2.76A ) 6TKM (X-ray 2.70A ) 6TKN (X-ray 2.50A ) 6TKP (X-ray 2.40A ) 6TKQ (X-ray 2.50A ) 6TKR (X-ray 2.75A ) 6TKS (X-ray 2.50A ) 7A1S (X-ray 2.01A ) 7O6X (X-ray 2.20A ) 7POX (X-ray 2.50A ) |
DBSNP | NA |
Subcellular location [CC] | Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Nucleus. Chromosome, telomere {ECO:0000305}. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1. |
Mouse PG classification | NA |
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