Gene Information
Gene NameTNKS2
OrganismHomo sapiens (Human)
Gene Length1166
Protein NamesPoly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein)
Target Nametankyrase-2
Target TypeClinical trial target
Gene Age680 ( ENSG00000107854 )
Evolutionary StageEukaryota
AlphaFoldDBQ9H2K2
Gene CardTNKS2
Uniprot IDQ9H2K2
PfamPF00023; PF12796; PF13637; PF13857; PF00644; PF07647
In ASDno
Allosteric Predictionno (-0.523602322)
Ortholog in AnimalsAlpaca_ TNKS2 ( ortholog_one2one )
Dog_ TNKS2 ( ortholog_one2one )
GuineaPig_ TNKS2 ( ortholog_one2one )
Macaque_ TNKS2 ( ortholog_one2one )
Mouse_ Tnks2 ( ortholog_one2one )
Pig_ TNKS2 ( ortholog_one2one )
Rat_ Tnks2 ( ortholog_one2one )
Rabbit_ TNKS2 ( ortholog_one2one )
OhnologsTNKS
ParalogsANKRD45, TNKS
TissueNA
Tissue SpecificityHighly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.022222(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2Y0I  (X-ray  2.28A  3KR7  (X-ray  1.95A  3KR8  (X-ray  2.10A  3MHJ  (X-ray  1.80A  3MHK  (X-ray  2.30A  3P0N  (X-ray  1.90A  3P0P  (X-ray  2.49A  3P0Q  (X-ray  1.90A  3TWQ  (X-ray  2.15A  3TWR  (X-ray  1.55A  3TWS  (X-ray  1.70A  3TWT  (X-ray  1.85A  3TWU  (X-ray  1.80A  3TWV  (X-ray  2.30A  3TWW  (X-ray  2.00A  3TWX  (X-ray  1.80A  3U9H  (X-ray  1.75A  3U9Y  (X-ray  2.30A  3UA9  (X-ray  2.15A  3W51  (X-ray  2.00A  4AVU  (X-ray  2.40A  4AVW  (X-ray  2.15A  4BFP  (X-ray  2.40A  4BJ9  (X-ray  2.05A  4BJB  (X-ray  2.30A  4BJC  (X-ray  2.20A  4BS4  (X-ray  1.89A  4BU3  (X-ray  2.15A  4BU5  (X-ray  1.80A  4BU6  (X-ray  1.80A  4BU7  (X-ray  2.05A  4BU8  (X-ray  1.85A  4BU9  (X-ray  1.65A  4BUA  (X-ray  1.85A  4BUD  (X-ray  2.50A  4BUE  (X-ray  1.60A  4BUF  (X-ray  2.50A  4BUI  (X-ray  1.95A  4BUS  (X-ray  1.90A  4BUT  (X-ray  1.90A  4BUU  (X-ray  1.60A  4BUV  (X-ray  1.80A  4BUW  (X-ray  1.85A  4BUX  (X-ray  1.95A  4BUY  (X-ray  1.90A  4HKI  (X-ray  2.15A  4HKK  (X-ray  1.95A  4HKN  (X-ray  2.05A  4HL5  (X-ray  2.20A  4HLF  (X-ray  2.15A  4HLG  (X-ray  2.00A  4HLH  (X-ray  1.75A  4HLK  (X-ray  2.00A  4HLM  (X-ray  1.95A  4HMH  (X-ray  2.30A  4HYF  (X-ray  2.80A  4IUE  (X-ray  2.38A  4J1Z  (X-ray  2.00A  4J21  (X-ray  1.93A  4J22  (X-ray  2.12A  4J3L  (X-ray  2.09A  4J3M  (X-ray  1.90A  4KZL  (X-ray  2.00A  4KZQ  (X-ray  2.25A  4KZU  (X-ray  2.10A  4L09  (X-ray  2.05A  4L0B  (X-ray  1.80A  4L0I  (X-ray  2.30A  4L0S  (X-ray  1.90A  4L0T  (X-ray  2.10A  4L0V  (X-ray  1.70A  4L10  (X-ray  1.70A  4L2F  (X-ray  2.05A  4L2G  (X-ray  2.05A  4L2K  (X-ray  2.10A  4L31  (X-ray  2.00A  4L32  (X-ray  1.85A  4L33  (X-ray  2.10A  4L34  (X-ray  1.80A  4M7B  (X-ray  1.95A  4PML  (X-ray  1.87A  4PNL  (X-ray  1.50A  4PNM  (X-ray  2.19A  4PNN  (X-ray  1.65A  4PNQ  (X-ray  1.85A  4PNR  (X-ray  1.71A  4PNS  (X-ray  1.65A  4PNT  (X-ray  1.60A  4TJU  (X-ray  1.57A  4TJW  (X-ray  1.70A  4TJY  (X-ray  1.90A  4TK0  (X-ray  1.65A  4TK5  (X-ray  2.02A  4TKF  (X-ray  2.60A  4TKG  (X-ray  1.95A  4TKI  (X-ray  2.15A  4UFU  (X-ray  2.10A  4UFY  (X-ray  1.70A  4UHG  (X-ray  1.70A  4UI3  (X-ray  2.00A  4UI4  (X-ray  2.40A  4UI5  (X-ray  1.65A  4UI6  (X-ray  1.80A  4UI7  (X-ray  1.80A  4UI8  (X-ray  2.05A  4UVL  (X-ray  2.00A  4UVN  (X-ray  2.20A  4UVO  (X-ray  1.85A  4UVP  (X-ray  1.75A  4UVS  (X-ray  2.00A  4UVT  (X-ray  1.95A  4UVU  (X-ray  1.95A  4UVV  (X-ray  1.90A  4UVW  (X-ray  2.10A  4UVX  (X-ray  1.95A  4UVY  (X-ray  1.95A  4UVZ  (X-ray  1.60A  4UX4  (X-ray  1.80A  4W5I  (X-ray  1.95A  4Z68  (X-ray  1.86A  5ADQ  (X-ray  2.10A  5ADR  (X-ray  2.10A  5ADS  (X-ray  1.80A  5ADT  (X-ray  2.15A  5AEH  (X-ray  1.85A  5AKU  (X-ray  1.80A  5AKW  (X-ray  2.07A  5AL1  (X-ray  1.75A  5AL2  (X-ray  1.90A  5AL3  (X-ray  1.75A  5AL4  (X-ray  1.90A  5AL5  (X-ray  2.05A  5BXO  (X-ray  1.33A  5BXU  (X-ray  1.35A  5C5P  (X-ray  1.75A  5C5Q  (X-ray  2.00A  5C5R  (X-ray  1.55A  5DCZ  (X-ray  2.23A  5FPF  (X-ray  2.60A  5FPG  (X-ray  2.75A  5JRT  (X-ray  1.53A  5NOB  (X-ray  1.85A  5NSP  (X-ray  2.30A  5NUT  (X-ray  1.60A  5OWS  (X-ray  1.80A  5OWT  (X-ray  2.20A  6TG4  (X-ray  2.76A  6TKM  (X-ray  2.70A  6TKN  (X-ray  2.50A  6TKP  (X-ray  2.40A  6TKQ  (X-ray  2.50A  6TKR  (X-ray  2.75A  6TKS  (X-ray  2.50A  7A1S  (X-ray  2.01A  7O6X  (X-ray  2.20A  7POX  (X-ray  2.50A 
DBSNP NA 
Subcellular location [CC]Cytoplasm. Golgi apparatus membrane;
Peripheral membrane protein. Nucleus. Chromosome, telomere {ECO:0000305}. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
Mouse PG classificationNA
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