| Gene Information | |
|---|---|
| Gene Name | TNKS |
| Organism | Homo sapiens (Human) |
| Gene Length | 1327 |
| Protein Names | Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1) |
| Target Name | tankyrase-1 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000173273 ) 3 ( ENSG00000285372 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95271 |
| Gene Card | TNKS |
| Uniprot ID | O95271 |
| Pfam | PF00023; PF12796; PF13606; PF13637; PF13857; PF00644; PF07647 |
| In ASD | no |
| Allosteric Prediction | no (-0.336781293) |
| Ortholog in Animals | Alpaca_ TNKS ( ortholog_one2one ) Dog_ TNKS ( ortholog_one2one ) GuineaPig_ TNKS ( ortholog_one2one ) Macaque_ TNKS ( ortholog_one2one ) Mouse_ Tnks ( ortholog_one2one ) Pig_ TNKS ( ortholog_one2one ) Rat_ Tnks ( ortholog_one2one ) Rabbit_ TNKS ( ortholog_one2one ) |
| Ohnologs | TNKS2 |
| Paralogs | ANKRD45, TNKS2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous; highest levels in testis. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002323(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2RF5 (X-ray 2.30A ) 3UDD (X-ray 1.95A ) 3UH2 (X-ray 2.00A ) 3UH4 (X-ray 2.00A ) 4DVI (X-ray 1.90A ) 4I9I (X-ray 2.40A ) 4K4E (X-ray 2.30A ) 4K4F (X-ray 2.90A ) 4KRS (X-ray 2.29A ) 4LI6 (X-ray 2.05A ) 4LI7 (X-ray 2.20A ) 4LI8 (X-ray 2.52A ) 4MSG (X-ray 1.80A ) 4MSK (X-ray 2.30A ) 4MT9 (X-ray 2.00A ) 4N3R (X-ray 1.90A ) 4N4V (X-ray 2.00A ) 4OA7 (X-ray 2.30A ) 4TOR (X-ray 1.50A ) 4TOS (X-ray 1.80A ) 4U6A (X-ray 2.37A ) 4UUH (X-ray 2.52A ) 4UW1 (X-ray 3.37A ) 4W5S (X-ray 2.80A ) 4W6E (X-ray 1.95A ) 5EBT (X-ray 2.24A ) 5ECE (X-ray 2.20A ) 5ETY (X-ray 2.90A ) 5GP7 (X-ray 1.50A ) 5JHQ (X-ray 3.20A ) 5JTI (X-ray 2.90A ) 5JU5 (X-ray 2.50A ) 5KNI (X-ray 2.50A ) 6QXU (X-ray 1.20A ) 6URQ (X-ray 2.05A ) 7KKM (X-ray 1.58A ) 7KKN (X-ray 1.48A ) 7KKO (X-ray 1.56A ) 7KKP (X-ray 1.40A ) 7KKQ (X-ray 1.59A ) 7OCV (X-ray 1.43A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10523501, ECO:0000269|PubMed:21799911, ECO:0000269|PubMed:22864114}. Golgi apparatus membrane {ECO:0000269|PubMed:22864114}; Peripheral membrane protein {ECO:0000269|PubMed:22864114}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:10523501, ECO:0000269|PubMed:21799911}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:10523501}. Chromosome, telomere {ECO:0000305|PubMed:9822378}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16076287}. Note=Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles (PubMed:22864114). A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres (PubMed:10523501). During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1 (PubMed:12768206). Localizes to spindle poles at mitosis onset via interaction with NUMA1 (PubMed:12080061). {ECO:0000269|PubMed:10523501, ECO:0000269|PubMed:12080061, ECO:0000269|PubMed:12768206, ECO:0000269|PubMed:22864114}. |
| Mouse PG classification | NA |
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