| Gene Information | |
|---|---|
| Gene Name | TNK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 666 |
| Protein Names | Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1) |
| Target Name | non-receptor tyrosine-protein kinase tnk1 |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000174292 ) 3 ( ENSG00000283781 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13470 |
| Gene Card | TNK1 |
| Uniprot ID | Q13470 |
| Pfam | PF07714 |
| In ASD | no |
| Allosteric Prediction | no (-0.401292467) |
| Ortholog in Animals | Alpaca_ TNK1 ( ortholog_one2one ) Dog_ TNK1 ( ortholog_one2one ) GuineaPig_ TNK1 ( ortholog_one2one ) Macaque_ TNK1 ( ortholog_one2one ) Mouse_ Tnk1 ( ortholog_one2one ) Pig_ TNK1 ( ortholog_one2one ) Rat_ Tnk1 ( ortholog_one2one ) Rabbit_ TNK1 ( ortholog_one2one ) |
| Ohnologs | TNK2 |
| Paralogs | FGR, FRK, JAK3, BMX, FER, BTK, FES, BLK, JAK1, PTK2B, SYK, TYK2, LYN, ZAP70, TXK, TNK2, PTK2, SRMS, TEC, CSK, STYK1, YES1, LCK, SRC, JAK2, ITK, MATK, HCK, ABL1, ABL2, FYN, PTK6 |
| Tissue | NA |
| Tissue Specificity | Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. {ECO:0000269|PubMed:10873601, ECO:0000269|PubMed:8632913}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs55939858 rs55641092 rs36046975 rs56093628 rs6503018 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:10873601}. Membrane {ECO:0000269|PubMed:10873601}; Peripheral membrane protein {ECO:0000269|PubMed:10873601}. |
| Mouse PG classification | NA |
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