| Gene Information | |
|---|---|
| Gene Name | TNIK |
| Organism | Homo sapiens (Human) |
| Gene Length | 1360 |
| Protein Names | TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1) |
| Target Name | traf2 and nck-interacting protein kinase |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000154310 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9UKE5 |
| Gene Card | TNIK |
| Uniprot ID | Q9UKE5 |
| Pfam | PF00780; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.040556469) |
| Ortholog in Animals | Alpaca_ TNIK ( ortholog_one2one ) Dog_ TNIK ( ortholog_one2one ) GuineaPig_ TNIK ( ortholog_one2one ) Macaque_ TNIK ( ortholog_one2one ) Mouse_ Tnik ( ortholog_one2one ) Pig_ TNIK ( ortholog_one2one ) Rat_ Tnik ( ortholog_one2one ) Rabbit_ TNIK ( ortholog_one2one ) |
| Ohnologs | MINK1, MAP4K4 |
| Paralogs | PAK5, PAK6, PAK4, SBK2, STK39, MAP4K1, PAK2, PAK1, PAK3, MAP4K5, SLK, MAP3K14, MAP3K19, STRADB, STK4, MAP3K1, TAOK2, MAP4K3, NRK, STRADA, MAP2K3, STK10, MAP2K6, STK26, TAOK3, TAOK1, MAP3K8, MAP4K2, OXSR1, STK3, NEK4, STK25, STK24, MAP4K4, MINK1 |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:19816403}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2X7F (X-ray 2.80A ) 5AX9 (X-ray 2.40A ) 5CWZ (X-ray 2.90A ) 5D7A (X-ray 2.90A ) 6RA5 (X-ray 2.90A ) 6RA7 (X-ray 1.20A ) |
| DBSNP | rs55778284 rs35090763 rs17857452 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression. |
| Mouse PG classification | NA |
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