| Gene Information | |
|---|---|
| Gene Name | TNFSF13B |
| Organism | Homo sapiens (Human) |
| Gene Length | 285 |
| Protein Names | Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form] |
| Target Name | b-cell-activating factor |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000102524 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9Y275 |
| Gene Card | TNFSF13B |
| Uniprot ID | Q9Y275 |
| Pfam | PF00229 |
| In ASD | no |
| Allosteric Prediction | yes (0.037473297) |
| Ortholog in Animals | Alpaca_ TNFSF13B ( ortholog_one2one ) Dog_ TNFSF13B ( ortholog_one2one ) GuineaPig_ TNFSF13B ( ortholog_one2one ) Macaque_ TNFSF13B ( ortholog_one2one ) Mouse_ Tnfsf13b ( ortholog_one2one ) Pig_ TNFSF13B ( ortholog_one2one ) Rat_ Tnfsf13b ( ortholog_one2one ) Rabbit_ TNLG7A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFSF13, TNFSF12 |
| Tissue | whole.blood |
| Tissue Specificity | Abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. Also found in the spleen, lymph node, bone marrow, T-cells and dendritic cells. A lower expression seen in placenta, heart, lung, fetal liver, thymus, and pancreas. Isoform 2 is expressed in many myeloid cell lines. {ECO:0000269|PubMed:12867412}. |
| Pharmacological Animal Models | 0.022255(Chimpanzee);0.001000(Mouse);NULL(Rat);0.046154(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1JH5 (X-ray 3.00A ) 1KD7 (X-ray 2.80A ) 1KXG (X-ray 2.00A ) 1OQD (X-ray 2.60A ) 1OQE (X-ray 2.50A ) 1OSG (X-ray 3.00A ) 3V56 (X-ray 3.00A ) 4V46 (X-ray 3.30A ) 4ZCH (X-ray 2.43A ) 5Y9J (X-ray 2.05A ) 6FXN (X-ray 2.90A ) |
| DBSNP | rs201543678 |
| Subcellular location [CC] | Cell membrane; Single-pass type II membrane protein.; [Tumor necrosis factor ligand superfamily member 13b, soluble form]: Secreted. |
| Mouse PG classification | NA |
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