| Gene Information | |
|---|---|
| Gene Name | TNFSF12 |
| Organism | Homo sapiens (Human) |
| Gene Length | 249 |
| Protein Names | Tumor necrosis factor ligand superfamily member 12 (APO3 ligand) (TNF-related weak inducer of apoptosis) (TWEAK) [Cleaved into: Tumor necrosis factor ligand superfamily member 12, membrane form; Tumor necrosis factor ligand superfamily member 12, secreted form] |
| Target Name | tnf-related weak inducer of apoptosis |
| Target Type | Clinical trial target |
| Gene Age | 168 ( ENSG00000239697 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O43508 |
| Gene Card | TNFSF12 |
| Uniprot ID | O43508 |
| Pfam | PF00229 |
| In ASD | no |
| Allosteric Prediction | no (-1.000178791) |
| Ortholog in Animals | Alpaca_ TNFSF12 ( ortholog_one2one ) Dog_ TNFSF12 ( ortholog_one2one ) GuineaPig_ TNFSF12 ( ortholog_one2one ) Macaque_ TNFSF12 ( ortholog_one2one ) Mouse_ Tnfsf12 ( ortholog_one2one ) Pig_ TNFSF12 ( ortholog_one2one ) Rat_ Tnfsf12 ( ortholog_one2one ) Rabbit_ TNFSF12 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFSF13, TNFSF13B |
| Tissue | NA |
| Tissue Specificity | Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4HT1 (X-ray 2.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12411489}; Single-pass type II membrane protein {ECO:0000269|PubMed:12411489}.; [Tumor necrosis factor ligand superfamily member 12, secreted form]: Secreted.; [Isoform TWE-PRIL]: Cell membrane; Single-pass membrane protein. |
| Mouse PG classification | NA |
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