| Gene Information | |
|---|---|
| Gene Name | TNFRSF8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 595 |
| Protein Names | Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30) |
| Target Name | lymphocyte activation antigen cd30 |
| Target Type | Successful target |
| Gene Age | 987 ( ENSG00000120949 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P28908 |
| Gene Card | TNFRSF8 |
| Uniprot ID | P28908 |
| Pfam | PF00020 |
| In ASD | no |
| Allosteric Prediction | yes (0.11695221) |
| Ortholog in Animals | Alpaca_ TNFRSF8 ( ortholog_one2one ) Dog_ MIIP ( ortholog_one2one ) Macaque_ TNFRSF8 ( ortholog_one2one ) Mouse_ Tnfrsf8 ( ortholog_one2one ) Rat_ Tnfrsf8 ( ortholog_one2one ) Rabbit_ TNFRSF8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFRSF25, TNFRSF6B, CD40, TNFRSF21, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, CD27, NGFR, FAS, TNFRSF10A, TNFRSF9, TNFRSF18, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF14, TNFRSF1B |
| Tissue | NA |
| Tissue Specificity | [Isoform 2]: Detected in alveolar macrophages (at protein level). {ECO:0000269|PubMed:8839832}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1D01 (X-ray 2.00A ) |
| DBSNP | rs2230624 rs2230624 rs1763642 rs2275170 rs2230625 rs35511003 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:8391931, ECO:0000305|PubMed:8999898}; Single-pass type I membrane protein {ECO:0000255}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:8839832}. |
| Mouse PG classification | NA |
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