| Gene Information | |
|---|---|
| Gene Name | TNFRSF4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 277 |
| Protein Names | Tumor necrosis factor receptor superfamily member 4 (ACT35 antigen) (OX40L receptor) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD antigen CD134) |
| Target Name | ox40l receptor |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000186827 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P43489 |
| Gene Card | TNFRSF4 |
| Uniprot ID | P43489 |
| Pfam | PF00020 |
| In ASD | no |
| Allosteric Prediction | no (-0.539038259) |
| Ortholog in Animals | Alpaca_ TNFRSF4 ( ortholog_one2one ) GuineaPig_ TNFRSF4 ( ortholog_one2one ) Macaque_ TNFRSF4 ( ortholog_one2one ) Mouse_ Tnfrsf4 ( ortholog_one2one ) Pig_ TNFRSF4 ( ortholog_one2one ) Rat_ Tnfrsf4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFRSF25, TNFRSF6B, CD40, TNFRSF21, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, CD27, NGFR, FAS, TNFRSF10A, TNFRSF9, TNFRSF18, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF14, TNFRSF1B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1D0A (X-ray 2.00A ) 2HEV (X-ray 2.41A ) 2HEY (X-ray 2.00A ) 6OGX (X-ray 2.77A ) 6OKM (X-ray 2.10A ) 6OKN (X-ray 3.25A ) |
| DBSNP | rs35304565 rs587777075 |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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