| Gene Information | |
|---|---|
| Gene Name | TNFRSF21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 655 |
| Protein Names | Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000146072 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O75509 |
| Gene Card | TNFRSF21 |
| Uniprot ID | O75509 |
| Pfam | PF00531; PF00020 |
| In ASD | no |
| Allosteric Prediction | yes (0.256076788) |
| Ortholog in Animals | Alpaca_ TNFRSF21 ( ortholog_one2one ) GuineaPig_ TNFRSF21 ( ortholog_one2one ) Macaque_ TNFRSF21 ( ortholog_one2one ) Mouse_ Tnfrsf21 ( ortholog_one2one ) Pig_ TNFRSF21 ( ortholog_one2one ) Rat_ Tnfrsf21 ( ortholog_one2one ) Rabbit_ TNFRSF21 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFRSF25, TNFRSF6B, CD40, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, CD27, NGFR, FAS, TNFRSF10A, TNFRSF9, TNFRSF18, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF14, TNFRSF1B |
| Tissue | NA |
| Tissue Specificity | Detected in fetal spinal cord and in brain neurons, with higher levels in brain from Alzheimer disease patients (at protein level). Highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. Detected at lower levels in lung, skeletal muscle, kidney, testis, uterus, small intestine, colon, spleen, bone marrow and fetal liver. Very low levels were found in adult liver and peripheral blood leukocytes. {ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:23559013, ECO:0000269|PubMed:9714541}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2DBH (NMR - ) 3QO4 (X-ray 2.20A ) 3U3P (X-ray 2.09A ) 3U3Q (X-ray 2.70A ) 3U3S (X-ray 2.70A ) 3U3T (X-ray 3.21A ) 3U3V (X-ray 2.96A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19654028}; Single-pass type I membrane protein {ECO:0000269|PubMed:19654028}. |
| Mouse PG classification | NA |
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