| Gene Information | |
|---|---|
| Gene Name | RAB21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 225 |
| Protein Names | Ras-related protein Rab-21 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000080371 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UL25 |
| Gene Card | RAB21 |
| Uniprot ID | Q9UL25 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-0.681536333) |
| Ortholog in Animals | Alpaca_ RAB21 ( ortholog_one2one ) GuineaPig_ RAB21 ( ortholog_one2one ) Macaque_ RAB21 ( ortholog_one2one ) Mouse_ Rab21 ( ortholog_one2one ) Pig_ RAB21 ( ortholog_one2one ) Rat_ Rab21 ( ortholog_one2one ) Rabbit_ RAB21 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RAB14, RAB5C, RAB39A, RAB27B, RAB36, RAB33B, RABL2A, RABL2B, RAB27A, RAB3C, RAB5A, RAB15, RAB40AL, RAB3A, RAB40C, RAB12, RAB8A, RAB17, RAB20, RAB24, RAB44, RAB1A, RAB11A, RAB31, RAB7A, IFT27, RAB29, RAB33A, RAB9B, RAB10, RAB4B, RAB32, RAB4A, RAB19, RAB42, RAB9A, RAB40A, RAB11B, RAB2B, RAB2A, RAB43, RAB18, RAB37, RAB25, RASEF, RAB6D, RAB6C, RAB8B, RAB41, RAB40B, RAB39B, RAB28, RAB5B, RAB13, RAB38, RAB3B, RAB34, RAB7B, RAB35, RAB3D, RAB1B, RAB6B, RAB22A, RAB26, RAB23, RAB30, RAB6A, DNAJC27 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression. {ECO:0000269|PubMed:10887961}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1YZT (X-ray 2.05A ) 1YZU (X-ray 2.50A ) 1Z08 (X-ray 1.80A ) 1Z0I (X-ray 2.33A ) 2OT3 (X-ray 2.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10887961}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19745841}. Golgi apparatus membrane {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:16525121, ECO:0000269|PubMed:25648148}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10887961}. Cleavage furrow {ECO:0000269|PubMed:18804435}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P35282}. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity). In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961). During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435). In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435). {ECO:0000250|UniProtKB:P35282, ECO:0000269|PubMed:10887961, ECO:0000269|PubMed:18804435}. |
| Mouse PG classification | NA |
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