| Gene Information | |
|---|---|
| Gene Name | TNFRSF10A |
| Organism | Homo sapiens (Human) |
| Gene Length | 468 |
| Protein Names | Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261) |
| Target Name | trail receptor 1 |
| Target Type | Clinical trial target |
| Gene Age | 987 ( ENSG00000104689 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O00220 |
| Gene Card | TNFRSF10A |
| Uniprot ID | O00220 |
| Pfam | PF00531; PF00020 |
| In ASD | no |
| Allosteric Prediction | yes (0.991665422) |
| Ortholog in Animals | Alpaca_ TNFRSF10A ( ortholog_one2one ) Macaque_ TNFRSF10A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TNFRSF25, TNFRSF6B, CD40, TNFRSF21, TNFRSF1A, TNFRSF10C, TNFRSF11B, TNFRSF10B, TNFRSF11A, CD27, NGFR, FAS, TNFRSF9, TNFRSF18, TNFRSF8, LTBR, RELT, TNFRSF10D, TNFRSF4, TNFRSF14, TNFRSF1B |
| Tissue | NA |
| Tissue Specificity | Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5CIR (X-ray 3.00A ) |
| DBSNP | rs34737614 rs20577 rs11986840 rs17620 rs20575 rs20576 rs17088980 rs2230229 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:22240897}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:19090789, ECO:0000269|PubMed:22240897}. Cytoplasm, cytosol {ECO:0000269|PubMed:22240897}. Note=Palmitoylation is required for association with membranes. {ECO:0000269|PubMed:22240897}. |
| Mouse PG classification | NA |
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