| Gene Information | |
|---|---|
| Gene Name | TNFAIP8L3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 292 |
| Protein Names | Tumor necrosis factor alpha-induced protein 8-like protein 3 (TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000183578 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q5GJ75 |
| Gene Card | TNFAIP8L3 |
| Uniprot ID | Q5GJ75 |
| Pfam | PF05527 |
| In ASD | no |
| Allosteric Prediction | no (-0.471654899) |
| Ortholog in Animals | Alpaca_ TNFAIP8L3 ( ortholog_one2one ) Dog_ TNFAIP8L3 ( ortholog_one2one ) GuineaPig_ TNFAIP8L3 ( ortholog_one2one ) Macaque_ TNFAIP8L3 ( ortholog_one2one ) Mouse_ Tnfaip8l3 ( ortholog_one2one ) Pig_ TNFAIP8L3 ( ortholog_one2one ) Rat_ Tnfaip8l3 ( ortholog_one2one ) Rabbit_ TNFAIP8L3 ( ortholog_one2one ) |
| Ohnologs | TNFAIP8L1, TNFAIP8, TNFAIP8L2 |
| Paralogs | TNFAIP8L1, TNFAIP8, TNFAIP8L2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed (at protein level) (PubMed:25479791). Highly expressed in most carcinoma cell lines (PubMed:25479791, PubMed:25242044). {ECO:0000269|PubMed:25242044, ECO:0000269|PubMed:25479791}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4Q9V (X-ray 2.30A ) |
| DBSNP | rs17647084 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:25479791}. Cell membrane {ECO:0000250|UniProtKB:Q3TBL6}. Note=On PDGF activation, translocates from cytoplasm to plasma membrane. {ECO:0000250|UniProtKB:Q3TBL6}. |
| Mouse PG classification | NA |
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