| Gene Information | |
|---|---|
| Gene Name | TNFA |
| Organism | Homo sapiens (Human) |
| Gene Length | 233 |
| Protein Names | Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P01375 |
| Gene Card | TNF |
| Uniprot ID | P01375 |
| Pfam | PF00229 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.355873(Rat);0.143210(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1A8M (X-ray 2.30A ) 1TNF (X-ray 2.60A ) 2AZ5 (X-ray 2.10A ) 2E7A (X-ray 1.80A ) 2TUN (X-ray 3.10A ) 2ZJC (X-ray 2.50A ) 2ZPX (X-ray 2.83A ) 3ALQ (X-ray 3.00A ) 3IT8 (X-ray 2.80A ) 3L9J (X-ray 2.10A ) 3WD5 (X-ray 3.10A ) 4G3Y (X-ray 2.60A ) 4TSV (X-ray 1.80A ) 4TWT (X-ray 2.85A ) 4Y6O (X-ray 1.60A ) 5M2I (X-ray 2.15A ) 5M2J (X-ray 1.90A ) 5M2M (X-ray 2.30A ) 5MU8 (X-ray 3.00A ) 5TSW (X-ray 2.50A ) 5UUI (X-ray 1.40A ) 5WUX (X-ray 2.90A ) 5YOY (X-ray 2.73A ) 6OOY (X-ray 2.50A ) 6OOZ (X-ray 2.80A ) 6OP0 (X-ray 2.55A ) 6RMJ (X-ray 2.65A ) 6X81 (X-ray 2.81A ) 6X82 (X-ray 2.75A ) 6X83 (X-ray 2.83A ) 6X85 (X-ray 2.85A ) 6X86 (X-ray 2.93A ) 7ASY (NMR - ) 7AT7 (NMR - ) 7ATB (NMR - ) 7JRA (X-ray 2.10A ) 7KP9 (X-ray 2.15A ) 7KPA (X-ray 2.30A ) 7KPB (X-ray 3.00A ) 7QLF (NMR - ) 7TA3 (X-ray 2.50A ) 7TA6 (X-ray 2.67A ) |
| DBSNP | rs4645843 rs1800620 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16829952}; Single-pass type II membrane protein {ECO:0000269|PubMed:16829952}.; [Tumor necrosis factor, membrane form]: Membrane; Single-pass type II membrane protein.; [Tumor necrosis factor, soluble form]: Secreted {ECO:0000269|PubMed:23552949}.; [C-domain 1]: Secreted.; [C-domain 2]: Secreted. |
| Mouse PG classification | NA |
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