| Gene Information | |
|---|---|
| Gene Name | TMX3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 454 |
| Protein Names | Protein disulfide-isomerase TMX3 (EC 5.3.4.1) (Thioredoxin domain-containing protein 10) (Thioredoxin-related transmembrane protein 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000166479 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96JJ7 |
| Gene Card | TMX3 |
| Uniprot ID | Q96JJ7 |
| Pfam | PF00085 |
| In ASD | no |
| Allosteric Prediction | no (-0.937275324) |
| Ortholog in Animals | Alpaca_ TMX3 ( ortholog_one2one ) Dog_ TMX3 ( ortholog_one2one ) GuineaPig_ TMX3 ( ortholog_one2one ) Macaque_ TMX3 ( ortholog_one2one ) Mouse_ Tmx3 ( ortholog_one2one ) Pig_ TMX3 ( ortholog_one2one ) Rat_ Tmx3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ERP27, PDIA6, TMX1, TXNDC11, TMX4, PDILT, ERP44, PDIA2, PDIA3, PDIA4, PDIA5, P4HB, TXNDC5 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in brain, testis, lung, skin, kidney, uterus, bone, stomach, liver, prostate, placenta, eye and muscle. {ECO:0000269|PubMed:15623505}. |
| Pharmacological Animal Models | 0.044130(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11557684 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15623505}; Single-pass membrane protein {ECO:0000269|PubMed:15623505}. |
| Mouse PG classification | NA |
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