| Gene Information | |
|---|---|
| Gene Name | TMX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 280 |
| Protein Names | Thioredoxin-related transmembrane protein 1 (Thioredoxin domain-containing protein 1) (Transmembrane Trx-related protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000139921 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9H3N1 |
| Gene Card | TMX1 |
| Uniprot ID | Q9H3N1 |
| Pfam | PF00085 |
| In ASD | no |
| Allosteric Prediction | no (-1.220127949) |
| Ortholog in Animals | Alpaca_ TMX1 ( ortholog_one2one ) Dog_ TMX1 ( ortholog_one2one ) GuineaPig_ TMX1 ( ortholog_one2one ) Macaque_ TMX1 ( ortholog_one2one ) Mouse_ Tmx1 ( ortholog_one2one ) Pig_ TMX1 ( ortholog_one2one ) Rat_ Tmx1 ( ortholog_one2one ) Rabbit_ TMX1 ( ortholog_one2one ) |
| Ohnologs | TMX4 |
| Paralogs | ERP27, PDIA6, TXNDC11, TMX4, TMX3, PDILT, ERP44, PDIA2, PDIA3, PDIA4, PDIA5, P4HB, TXNDC5 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highly expressed in kidney, liver, placenta and lung. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1X5E (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly found in the endoplasmic reticulum. {ECO:0000269|PubMed:11152479}. |
| Mouse PG classification | NA |
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