| Gene Information | |
|---|---|
| Gene Name | TMUB1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 246 |
| Protein Names | Transmembrane and ubiquitin-like domain-containing protein 1 (Dendritic cell-derived ubiquitin-like protein) (DULP) (Hepatocyte odd protein shuttling protein) (Ubiquitin-like protein SB144) [Cleaved into: iHOPS] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000164897 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BVT8 |
| Gene Card | TMUB1 |
| Uniprot ID | Q9BVT8 |
| Pfam | PF00240 |
| In ASD | no |
| Allosteric Prediction | no (-1.322979805) |
| Ortholog in Animals | Alpaca_ TMUB1 ( ortholog_one2one ) Dog_ TMUB1 ( ortholog_one2one ) GuineaPig_ TMUB1 ( ortholog_one2one ) Macaque_ TMUB1 ( ortholog_one2one ) Mouse_ Tmub1 ( ortholog_one2one ) Pig_ TMUB1 ( ortholog_one2one ) Rat_ Tmub1 ( ortholog_one2one ) Rabbit_ TMUB1 ( ortholog_one2one ) |
| Ohnologs | TMUB2 |
| Paralogs | TMUB2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed with highest levels in mammary and thyroid glands, bone marrow and spleen; limited expression in cardiac, pancreatic and ovarian tissues. {ECO:0000269|PubMed:24240191}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Membrane {ECO:0000250|UniProtKB:Q9JMG3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JMG3}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9JMG3}. Recycling endosome {ECO:0000250|UniProtKB:Q53AQ4}. Cytoplasm {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JMG3}.; [iHOPS]: Cytoplasm {ECO:0000250|UniProtKB:Q53AQ4, ECO:0000250|UniProtKB:Q9JMG3}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JMG3}. Nucleus {ECO:0000250|UniProtKB:Q9JMG3}. Note=iHOPS is proposed to be the shuttling form across different cellular compartments. XPO1-dependent exported from the nucleus in dividing cells. Predominantly nuclear during growth arrest. {ECO:0000250|UniProtKB:Q9JMG3}. |
| Mouse PG classification | NA |
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