Gene Information

Gene Information
Gene Name	KIAA0086
Organism	Homo sapiens (Human)
Gene Length	1040
Protein Names	DNA cross-link repair 1A protein (Beta-lactamase DCLRE1A) (EC 3.5.2.6) (SNM1 homolog A) (hSNM1) (hSNM1A)
Target Name	NA
Target Type	NA
Gene Age	NA
Evolutionary Stage	NA
AlphaFoldDB	Q6PJP8
Gene Card	DCLRE1A
Uniprot ID	Q6PJP8
Pfam	PF07522
In ASD	no
Allosteric Prediction	NA
Ortholog in Animals	NA
Ohnologs	NA
Paralogs	NA
Tissue	NA
Tissue Specificity	Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle. {ECO:0000269\|PubMed:12446782}.
Pharmacological Animal Models	NA
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	4B87 (X-ray 2.16A ) 5AHR (X-ray 2.19A ) 5NZW (X-ray 2.70A ) 5NZX (X-ray 1.47A ) 5NZY (X-ray 1.55A ) 5Q1J (X-ray 1.42A ) 5Q1K (X-ray 1.42A ) 5Q1L (X-ray 1.76A ) 5Q1M (X-ray 1.56A ) 5Q1N (X-ray 1.38A ) 5Q1O (X-ray 1.25A ) 5Q1P (X-ray 1.56A ) 5Q1Q (X-ray 1.44A ) 5Q1R (X-ray 1.49A ) 5Q1S (X-ray 1.62A ) 5Q1T (X-ray 1.49A ) 5Q1U (X-ray 1.50A ) 5Q1V (X-ray 1.57A ) 5Q1W (X-ray 1.68A ) 5Q1X (X-ray 1.42A ) 5Q1Y (X-ray 1.42A ) 5Q1Z (X-ray 1.41A ) 5Q20 (X-ray 1.76A ) 5Q22 (X-ray 1.18A ) 5Q23 (X-ray 1.32A ) 5Q24 (X-ray 1.35A ) 5Q25 (X-ray 1.43A ) 5Q26 (X-ray 1.66A ) 5Q27 (X-ray 1.83A ) 5Q28 (X-ray 1.52A ) 5Q29 (X-ray 1.46A ) 5Q2A (X-ray 1.50A ) 5Q2B (X-ray 1.33A ) 5Q2C (X-ray 1.53A ) 5Q2D (X-ray 1.40A ) 5Q2E (X-ray 1.50A ) 5Q2F (X-ray 1.47A ) 5Q2G (X-ray 1.49A ) 5Q2H (X-ray 1.72A ) 5Q2I (X-ray 2.33A ) 5Q2J (X-ray 1.30A ) 5Q2K (X-ray 1.65A ) 5Q2L (X-ray 1.42A ) 5Q2M (X-ray 1.28A ) 5Q2N (X-ray 1.38A ) 5Q2O (X-ray 1.75A ) 5Q2P (X-ray 1.55A ) 5Q2Q (X-ray 1.44A ) 5Q2R (X-ray 1.37A ) 5Q2S (X-ray 1.52A ) 5Q2T (X-ray 1.52A ) 5Q2U (X-ray 1.37A ) 5Q2V (X-ray 1.58A ) 5Q2W (X-ray 1.53A ) 5Q2X (X-ray 1.50A ) 5Q2Y (X-ray 1.61A ) 5Q2Z (X-ray 1.55A ) 5Q30 (X-ray 1.80A ) 5Q31 (X-ray 1.55A ) 5Q32 (X-ray 1.87A ) 5Q33 (X-ray 1.37A ) 5Q34 (X-ray 1.49A ) 5Q35 (X-ray 1.47A ) 5Q36 (X-ray 1.39A ) 5Q37 (X-ray 1.50A ) 5Q38 (X-ray 1.39A ) 5Q39 (X-ray 1.70A ) 5Q3A (X-ray 1.48A ) 5Q3B (X-ray 2.52A ) 5Q3C (X-ray 1.41A ) 5Q3D (X-ray 1.71A ) 5Q3E (X-ray 1.49A ) 5Q3F (X-ray 1.39A ) 5Q3G (X-ray 1.29A ) 5Q3H (X-ray 1.56A ) 5Q3I (X-ray 1.53A ) 5Q3J (X-ray 1.44A ) 5Q3K (X-ray 1.39A ) 5Q3L (X-ray 1.61A ) 5Q3M (X-ray 1.34A ) 5Q3N (X-ray 1.62A ) 5Q3O (X-ray 1.60A ) 5Q3P (X-ray 1.44A ) 5Q3Q (X-ray 1.39A ) 5Q3R (X-ray 1.50A ) 5Q3S (X-ray 1.72A ) 5Q3T (X-ray 1.52A ) 5Q3U (X-ray 1.49A ) 5Q3V (X-ray 1.52A ) 5Q3W (X-ray 1.50A ) 5Q3X (X-ray 1.38A ) 5Q3Y (X-ray 1.45A ) 5Q3Z (X-ray 1.84A ) 5Q40 (X-ray 2.04A ) 5Q41 (X-ray 1.95A ) 5Q42 (X-ray 1.68A ) 5Q43 (X-ray 1.47A ) 5Q44 (X-ray 1.55A ) 5Q45 (X-ray 1.64A ) 5Q46 (X-ray 2.01A ) 5Q47 (X-ray 1.38A ) 5Q48 (X-ray 1.44A ) 5Q49 (X-ray 1.38A ) 5Q4A (X-ray 1.83A ) 5Q4B (X-ray 1.60A ) 5Q4C (X-ray 2.73A ) 5Q4D (X-ray 1.80A ) 5Q4E (X-ray 1.39A ) 5Q4F (X-ray 1.97A ) 5Q4G (X-ray 1.75A ) 5Q4H (X-ray 1.53A ) 5Q4I (X-ray 1.55A ) 5Q4J (X-ray 1.55A ) 5Q4K (X-ray 1.47A ) 5Q4L (X-ray 1.60A ) 5Q4M (X-ray 1.60A ) 5Q4N (X-ray 1.71A ) 5Q4O (X-ray 1.83A ) 5Q4P (X-ray 1.40A ) 5Q4Q (X-ray 1.42A ) 5Q4R (X-ray 2.00A ) 5Q4S (X-ray 1.72A ) 5Q4T (X-ray 1.77A ) 5Q4U (X-ray 2.00A ) 5Q4V (X-ray 1.59A ) 5Q4W (X-ray 1.80A ) 5Q4X (X-ray 1.66A ) 5Q4Y (X-ray 1.69A ) 5Q4Z (X-ray 1.60A ) 5Q50 (X-ray 2.00A ) 5Q51 (X-ray 1.34A ) 5Q52 (X-ray 1.70A ) 5Q53 (X-ray 1.55A ) 5Q54 (X-ray 1.30A ) 5Q55 (X-ray 1.39A ) 5Q56 (X-ray 1.87A ) 5Q57 (X-ray 1.65A ) 5Q58 (X-ray 1.75A ) 5Q59 (X-ray 1.86A ) 5Q5A (X-ray 2.26A ) 5Q5B (X-ray 1.58A ) 5Q5C (X-ray 1.38A ) 5Q5D (X-ray 1.71A ) 5Q5E (X-ray 1.49A ) 5Q5F (X-ray 1.47A ) 5Q5G (X-ray 2.00A ) 5Q5H (X-ray 1.36A ) 5Q5I (X-ray 1.65A ) 5Q5J (X-ray 2.00A ) 5Q5K (X-ray 2.81A ) 5Q5L (X-ray 2.00A ) 5Q5M (X-ray 1.57A ) 5Q5N (X-ray 2.42A ) 5Q5O (X-ray 2.07A ) 5Q5P (X-ray 1.58A ) 5Q5Q (X-ray 1.45A ) 5Q5R (X-ray 1.39A ) 5Q5S (X-ray 1.70A ) 5Q5T (X-ray 1.80A ) 5Q5U (X-ray 1.88A ) 5Q5V (X-ray 1.86A ) 5Q5W (X-ray 1.42A ) 5Q5X (X-ray 1.50A ) 5Q5Y (X-ray 1.82A ) 5Q5Z (X-ray 1.48A ) 5Q60 (X-ray 1.40A ) 5Q61 (X-ray 1.71A ) 5Q62 (X-ray 1.52A ) 5Q63 (X-ray 1.82A ) 5Q64 (X-ray 1.42A ) 5Q65 (X-ray 1.78A ) 5Q66 (X-ray 1.51A ) 5Q67 (X-ray 1.65A ) 5Q68 (X-ray 1.86A ) 5Q69 (X-ray 1.84A ) 5Q6A (X-ray 1.71A ) 5Q6B (X-ray 2.62A ) 5Q6C (X-ray 1.53A ) 5Q6D (X-ray 1.48A ) 5Q6E (X-ray 1.47A ) 5Q6F (X-ray 1.55A ) 5Q6G (X-ray 1.48A ) 5Q6H (X-ray 1.42A ) 5Q6I (X-ray 1.68A ) 5Q6J (X-ray 1.70A ) 5Q6K (X-ray 1.67A ) 5Q6L (X-ray 1.82A ) 5Q6M (X-ray 1.47A ) 5Q6N (X-ray 1.52A ) 5Q6O (X-ray 1.40A ) 5Q6P (X-ray 1.54A ) 5Q6Q (X-ray 1.36A ) 5Q6R (X-ray 1.42A ) 5Q6S (X-ray 1.56A ) 5Q6T (X-ray 1.59A ) 5Q6U (X-ray 1.33A ) 5Q6V (X-ray 1.29A ) 5Q6W (X-ray 1.50A ) 5Q6X (X-ray 1.43A ) 5Q6Y (X-ray 1.67A ) 5Q6Z (X-ray 1.62A ) 5Q70 (X-ray 1.31A ) 5Q71 (X-ray 2.00A ) 5Q72 (X-ray 1.31A ) 5Q73 (X-ray 1.36A ) 5Q74 (X-ray 1.21A ) 5Q75 (X-ray 1.36A ) 5Q76 (X-ray 1.28A ) 5Q77 (X-ray 2.00A ) 5Q78 (X-ray 1.25A ) 5Q79 (X-ray 1.83A ) 5Q7A (X-ray 1.39A ) 5Q7B (X-ray 1.25A ) 5Q7C (X-ray 1.20A ) 5Q7D (X-ray 1.32A ) 5Q7E (X-ray 1.50A ) 5Q7F (X-ray 1.64A ) 5Q7G (X-ray 2.00A ) 5Q7H (X-ray 2.00A ) 5Q7I (X-ray 1.26A ) 5Q7J (X-ray 1.54A ) 5Q7K (X-ray 2.00A ) 5Q7L (X-ray 1.61A ) 5Q7M (X-ray 1.26A ) 5Q7N (X-ray 2.00A ) 5Q7O (X-ray 1.32A ) 5Q7P (X-ray 2.00A ) 5Q7Q (X-ray 1.76A ) 5Q7R (X-ray 1.62A ) 5Q7S (X-ray 1.31A ) 5Q7T (X-ray 1.67A ) 5Q7U (X-ray 2.11A ) 5Q7V (X-ray 1.62A ) 5Q7W (X-ray 1.27A ) 5Q7X (X-ray 1.69A ) 5Q7Y (X-ray 1.39A ) 5Q7Z (X-ray 1.65A ) 5Q80 (X-ray 1.43A ) 5Q81 (X-ray 1.51A ) 5Q82 (X-ray 1.20A ) 5Q83 (X-ray 1.28A ) 5Q84 (X-ray 1.88A ) 5Q85 (X-ray 1.80A ) 5Q86 (X-ray 1.31A ) 5Q87 (X-ray 1.34A ) 5Q88 (X-ray 1.78A ) 5Q89 (X-ray 1.91A ) 5Q8A (X-ray 1.43A ) 5Q8B (X-ray 1.63A ) 5Q8C (X-ray 2.00A ) 5Q8D (X-ray 1.23A ) 5Q8E (X-ray 1.63A ) 5Q8F (X-ray 1.36A ) 5Q8G (X-ray 2.00A ) 5Q8H (X-ray 1.90A ) 5Q8I (X-ray 1.35A ) 5Q8J (X-ray 1.79A ) 5Q8K (X-ray 1.79A ) 5Q8L (X-ray 1.42A ) 5Q8M (X-ray 1.71A ) 5Q8N (X-ray 1.41A ) 5Q8O (X-ray 1.67A ) 5Q8P (X-ray 1.45A ) 5Q8Q (X-ray 1.89A ) 5Q8R (X-ray 1.90A ) 5Q8S (X-ray 1.61A ) 5Q8T (X-ray 2.00A ) 5Q8U (X-ray 1.54A ) 5Q8V (X-ray 1.32A ) 5Q8W (X-ray 1.57A ) 5Q8X (X-ray 1.23A ) 5Q8Y (X-ray 1.51A ) 5Q8Z (X-ray 1.47A ) 5Q90 (X-ray 1.49A ) 5Q91 (X-ray 1.46A ) 5Q92 (X-ray 2.11A ) 5Q93 (X-ray 1.68A ) 5Q94 (X-ray 1.90A ) 5Q95 (X-ray 1.47A ) 5Q96 (X-ray 1.83A ) 5Q97 (X-ray 1.97A ) 5Q98 (X-ray 1.76A ) 5Q99 (X-ray 1.31A ) 5Q9A (X-ray 1.67A ) 5Q9B (X-ray 1.45A ) 5Q9C (X-ray 1.46A ) 5Q9D (X-ray 1.69A ) 5Q9E (X-ray 1.45A ) 5Q9F (X-ray 1.28A ) 5Q9G (X-ray 1.60A ) 5Q9H (X-ray 1.81A ) 5Q9I (X-ray 1.46A ) 5Q9J (X-ray 1.76A ) 5Q9K (X-ray 1.78A ) 5Q9L (X-ray 1.59A ) 5Q9M (X-ray 1.30A ) 5Q9N (X-ray 1.47A ) 5Q9O (X-ray 1.37A ) 5Q9P (X-ray 1.48A ) 5Q9Q (X-ray 1.50A ) 5Q9R (X-ray 1.72A ) 5Q9S (X-ray 1.43A ) 5Q9T (X-ray 1.37A ) 5Q9U (X-ray 1.49A ) 5Q9V (X-ray 1.43A ) 5Q9W (X-ray 1.53A ) 5Q9X (X-ray 1.67A ) 5Q9Y (X-ray 1.64A ) 5Q9Z (X-ray 1.77A ) 5QA0 (X-ray 1.47A ) 5QA1 (X-ray 1.46A ) 5QA2 (X-ray 1.56A )
DBSNP	rs17235066 rs17228665 rs17228672 rs17235094 rs3750898 rs17855759 rs11196530
Subcellular location [CC]	Nucleus {ECO:0000269\|PubMed:10848582, ECO:0000269\|PubMed:12446782, ECO:0000269\|PubMed:15572677}. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1.
Mouse PG classification	NA
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