| Gene Information | |
|---|---|
| Gene Name | TMPRSS5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 457 |
| Protein Names | Transmembrane protease serine 5 (EC 3.4.21.-) (Spinesin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000166682 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9H3S3 |
| Gene Card | TMPRSS5 |
| Uniprot ID | Q9H3S3 |
| Pfam | PF15494; PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-1.406701249) |
| Ortholog in Animals | Alpaca_ TMPRSS5 ( ortholog_one2one ) Dog_ TMPRSS5 ( ortholog_one2one ) Macaque_ TMPRSS5 ( ortholog_one2one ) Mouse_ Tmprss5 ( ortholog_one2one ) Rat_ Tmprss5 ( ortholog_one2one ) Rabbit_ TMPRSS5 ( ortholog_one2one ) |
| Ohnologs | PRSS21, HPN, TMPRSS3, TPSAB1, PRSS36, TMPRSS2, TPSB2, TMPRSS11E, TMPRSS11B, PRSS38, TMPRSS11F |
| Paralogs | TMPRSS15, TMPRSS6, HPN, TMPRSS11E, ST14, TMPRSS3, TMPRSS13, TMPRSS11D, TMPRSS2, PRSS22, TMPRSS11A, TMPRSS7, TMPRSS11B, TMPRSS9, PRSS21, PRSS41, TMPRSS11F |
| Tissue | tibial.nerve |
| Tissue Specificity | Brain-specific. Predominantly expressed in neurons, in their axons, and at the synapses of motoneurons in the spinal cord. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11601425 rs7939917 rs1263487635 rs7110736 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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