| Gene Information | |
|---|---|
| Gene Name | TMPRSS6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 811 |
| Protein Names | Transmembrane protease serine 6 (EC 3.4.21.-) (Matriptase-2) |
| Target Name | tmprss6 messenger rna |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000187045 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8IU80 |
| Gene Card | TMPRSS6 |
| Uniprot ID | Q8IU80 |
| Pfam | PF00057; PF01390; PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-0.174741954) |
| Ortholog in Animals | Alpaca_ TMPRSS6 ( ortholog_one2one ) Dog_ TMPRSS6 ( ortholog_one2one ) GuineaPig_ TMPRSS6 ( ortholog_one2one ) Macaque_ TMPRSS6 ( ortholog_one2one ) Mouse_ Tmprss6 ( ortholog_one2one ) Pig_ TMPRSS6 ( ortholog_one2one ) Rat_ Tmprss6 ( ortholog_one2one ) |
| Ohnologs | PRSS22, PRSS21, PRSS8, PRSS33, ST14, PRSS27, PRSS36 |
| Paralogs | TMPRSS15, HPN, TMPRSS11E, ST14, TMPRSS3, TMPRSS13, TMPRSS11D, TMPRSS2, PRSS22, TMPRSS11A, TMPRSS7, TMPRSS11B, TMPRSS9, TMPRSS5, PRSS21, PRSS41, TMPRSS11F |
| Tissue | liver, brain |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs199474803 rs267607121 rs1430692214 rs776877803 rs749106338 rs754848810 rs199474802 rs2235324 rs2235324 rs776180387 rs1449962575 rs5995378 rs1373272804 rs199474804 rs137853119 rs117576908 rs137853120 rs387907018 rs770897887 rs773272073 rs769083817 rs855791 rs11703011 rs199474805 rs776069764 rs139105452 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18976966, ECO:0000269|PubMed:20518742, ECO:0000269|PubMed:25588876}; Single-pass type II membrane protein {ECO:0000269|PubMed:20518742}. Note=The processed, activated two-chains form is released in the extracellular space. {ECO:0000269|PubMed:25156943}. |
| Mouse PG classification | HPG |
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