Gene Information
Gene NameTMPRSS4
OrganismHomo sapiens (Human)
Gene Length437
Protein NamesTransmembrane protease serine 4 (EC 3.4.21.-) (Channel-activating protease 2) (CAPH2) (Membrane-type serine protease 2) (MT-SP2) [Cleaved into: Transmembrane protease serine 4 catalytic chain]
Target NameNA
Target TypeNA
Gene Age332 ( ENSG00000137648 )
Evolutionary StageEumetazoa
AlphaFoldDBQ9NRS4
Gene CardTMPRSS4
Uniprot IDQ9NRS4
PfamPF15494; PF00089
In ASDno
Allosteric Predictionno (-0.86421363)
Ortholog in AnimalsAlpaca_ TMPRSS4 ( ortholog_one2one )
Dog_ TMPRSS4 ( ortholog_one2one )
GuineaPig_ TMPRSS4 ( ortholog_one2one )
Macaque_ TMPRSS4 ( ortholog_one2one )
Mouse_ Tmprss4 ( ortholog_one2one )
Pig_ TMPRSS4 ( ortholog_one2one )
Rat_ Tmprss4 ( ortholog_one2one )
Rabbit_ TMPRSS4 ( ortholog_one2one )
OhnologsPRSS21, HPN, TMPRSS15, TMPRSS3, TMPRSS2, TMPRSS11E, TMPRSS11B, PRSS38, TMPRSS11F
ParalogsPRSS54, KLK11, KLK14, KLK7, KLK3, KLK2, KLK12, PRSS58, KLK8, KLK4, KLK5, KLK1
Tissuecolon, gall.bladder, esophagus.mucosa, transverse.colon
Tissue SpecificityHigh levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract (PubMed:10825129). Coexpressed with ACE2 within mature enterocytes (PubMed:32404436). {ECO:0000269|PubMed:10825129, ECO:0000269|PubMed:32404436}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs1894176  rs12270001  rs1941635 
Subcellular location [CC]Cell membrane {ECO:0000305|PubMed:24434139};
Single-pass type II membrane protein {ECO:0000305}.;
[Transmembrane protease serine 4 catalytic chain]: Secreted {ECO:0000269|PubMed:24434139}. Note=Activated by cleavage and secreted. {ECO:0000269|PubMed:24434139}.
Mouse PG classificationNA
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