| Gene Information | |
|---|---|
| Gene Name | TMPRSS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 454 |
| Protein Names | Transmembrane protease serine 3 (EC 3.4.21.-) (Serine protease TADG-12) (Tumor-associated differentially-expressed gene 12 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000160183 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P57727 |
| Gene Card | TMPRSS3 |
| Uniprot ID | P57727 |
| Pfam | PF00057; PF15494; PF00089 |
| In ASD | no |
| Allosteric Prediction | no (-0.439303491) |
| Ortholog in Animals | Alpaca_ TMPRSS3 ( ortholog_one2one ) Dog_ TMPRSS3 ( ortholog_one2one ) GuineaPig_ TMPRSS3 ( ortholog_one2one ) Macaque_ TMPRSS3 ( ortholog_one2one ) Mouse_ Tmprss3 ( ortholog_one2one ) Pig_ TMPRSS3 ( ortholog_one2one ) Rat_ Tmprss3 ( ortholog_one2one ) |
| Ohnologs | PRSS33, HPN, TPSG1, TMPRSS4, TMPRSS13, TMPRSS5 |
| Paralogs | TMPRSS15, TMPRSS6, HPN, TMPRSS11E, ST14, TMPRSS13, TMPRSS11D, TMPRSS2, PRSS22, TMPRSS11A, TMPRSS7, TMPRSS11B, TMPRSS9, TMPRSS5, PRSS21, PRSS41, TMPRSS11F |
| Tissue | oviduct, stomach, brain |
| Tissue Specificity | Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs928302 rs387906915 rs201632198 rs35227181 rs766000719 rs1333651774 rs137853000 rs137852999 rs2839500 rs28939084 rs773780151 rs56264519 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12393794}; Single-pass type II membrane protein {ECO:0000269|PubMed:12393794}. |
| Mouse PG classification | HPG |
| click here to return to the previous page | |